Non-invasive identification and monitoring of Inflammatory Bowel Disease (IBD)

该项目评估了一种新的，非侵入性的诊断和监测克罗恩病和溃疡性结肠炎试验的可行性。该测试基于使用新型离子迁移技术检测生物样品中的VOC生物标志物。克罗恩病和溃疡性结肠炎是特别令人不快的，影响1/250的人口。症状包括急性和带血腹泻，疼痛和持续疲劳，深度溃疡和肠壁疤痕。目前的诊断方法是高度侵入性的;基于血液检查和内窥镜检查（经直肠的摄像机检查）。NHS的费用定为每例手术500英镑，英国每年约有18万例手术。我们的创新步骤是用一种简单，低成本（低于10英镑）的尿液或粪便检测来取代这种方法，该方法基于对这些生物样本中释放的VOC生物标志物的检测和分析。

This project evaluates the feasibility of a novel, non-invasive diagnosis and monitoring test for crohn’s disease and ulcerative colitis. The test is based on the detection of VOC bio-markers in biological samples using a novel form Ion Mobility technology. Crohn’s disease and ulcerative colitis are particularly unpleasant affecting 1 in 250 of the population. Symptoms range from urgent and bloody diarrhea, pain and continual tiredness to deep ulcers and scarring to the wall of the intestine. Current diagnostic methods are highly invasive; being based on blood tests and endoscopic examinations (camera examination per rectum). The cost to the NHS is set at £500 per procedure with around 180,000 procedures undertaken per annum in the UK. Our innovative step is to replace this with a simple, low-cost (sub £10) urine or stool test based on the detection and analysis of VOC biomarkers released from these biological samples.