PHYSICIAN SCIENTIST PROGRAM AWARD

医生-科学家奖计划的持续目标描述于 此续期申请将同时满足我们的以下需求 为我们快速发展的Stein担任领导职务的调查人员 老龄化研究所，成立于大学校园 加州大学圣地亚哥分校于1983年成立。身份证明， 招聘，培养最聪明、最优秀的医学博士S进入 与老龄化相关的临床研究领域也将 达到国家老龄研究所(NIA)的目标。内科医生 在他们的早期临床培训将被邀请申请一个 五年的强化训练计划，将为他们配备强大的 真正富有成效的研究需要基础科学方向 生物医学问题。在这份提案中，重点是提供 为候选人进行问题研究做好准备的课程 与大约六个容易恶化的主要身体系统有关 随着时间的推移，病理学的作用和发展。第一 两三年的培训将是最基本的水平，以便 希望学员们能够利用前沿解决前沿问题。 方法：研究方法。在这一阶段的培训中，候选人将 分配给在布罗德大学基础学科工作的教师资助人 对生物医学问题的适用性。直接实验室研究 经验的补充将由旨在填补 基础科学背景方面的差距，以及弥补 曾接受过老年学和老年医学方面的教育。因此， 将自由使用丰富的基础科学课程菜单 在La Jolla校园提供，这将由一个 组织良好的老年病学/老年学课程。最后两三个 几年的培训将致力于研究与 NIA感兴趣的六个浓缩区之一的病理生理学。 加州大学圣迭戈分校教职员工计划的核心是从 生物和化学系在一般校园，和基础 和医学院的临床教员。他们每个人都是 根据他们在研究中被证明的生产力和他们的 培训项目的跟踪记录。其中包括四名获得 当选为国家科学院院士。所有人都将拥有自己的 以这些年轻调查人员的发展为目标，这样五年后 几年后，他们将准备好承担初级教员的全部责任 会员拥有自己的研究支持。因为不同寻常的 该计划的成功和持续的参与请求 优秀的年轻临床医生，我们请求支持10名 各就各位。

The continuing aims of the Physician-Scientist Award Program described in this renewal application will at the same time meet our needs for investigators in leadership positions for our rapidly-developing Stein Institute for Research on .Aging, established on the campus of the University of California San Diego in 1983. The identification, recruitment, and training of the brightest and best M. D.'s into the arena of clinical investigation on subjects related to aging will also meet the objectives of the National Institute on Aging (NIA). Physicians in their early years of clinical training will be invited to apply for a five-year intensive training program that will equip them with the strong basic science orientation needed for truly productive research on biomedical problems. Emphasis in this proposal is placed on providing tracks that will prepare candidates to carry out research on problems relating to some six major body systems that are prone to deterioration in function and development of pathology with advancing years. The first two or three years of training will be at the most basic level so that the trainees can, it is hoped, attack frontier problems using frontier methods. During this phase of their training, the candidates will be assigned to faculty sponsors working in fundamental disciplines of broad applicability to biomedical problems. Direct laboratory research experience will be supplemented by didactic training designed to fill gaps in their basic science background as well as to make up for gaps in previous education related to gerontology and geriatric medicine. Thus, liberal use will be made of the rich menu of basic science courses offered on the La Jolla campus and this will be supplemented by a well-organized course in geriatrics/gerontology. The last two or three years of training will be devoted to research problems bearing on the pathophysiology of one of the six concentration areas of interest to NIA. The nucleus of UCSD faculty planning for this program is drawn from the Departments of Biology and Chemistry on the general campus, and the basic and clinical faculty of the School of Medicine. They have each been selected on the basis of their proven productivity in research and their track records in training programs. Included are four faculty honored by election to the National Academy of Sciences. All will have as their goal the development of these young investigators so that after five years they will be ready for full responsibility as junior faculty members with their own research support. Because of the remarkable success of this program and continuing requests for participation by well-qualified young clinicians, we are requesting support for 10 positions.