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GOUTY ARTHRITIS IN PATIENTS WITH HETEROZYGOSITY FOR FRUCTOSE PHOSPHATE

GOUTY ARTHRITIS IN PATIENTS WITH HETEROZYGOSITY FOR FRUCTOSE PHOSPHATE
果糖磷酸杂合性患者的痛风性关节炎
批准号：
6279141
负责人：
J E SEEGMILLER
金额：
$1.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6279141
关键词：
arthritis clinical research family genetics fructose fructose phosphate gout human subject liver metabolism magnetic resonance imaging metabolism disorder diagnosis oral administration phosphoric ester purine /pyrimidine metabolism urate

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英文摘要
Identify patients with familial gouty arthritis who show evidence of accumulation of phosphomonoesters and depletion of inorganic phosphase on magntic resonance spectroscopic examination of their liver after ingestion of oral fructose. Determine the portion of patients in whom this is associated with a substantially higher than normal response of serum urate with the objective of identifying a more simple clinical test for this specific abnormality of metabolism.
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ORAL NICTOTINIC ACID FOR TREATMENT OF LESCH NYHAN PATIENTS
GOUTY ARTHRITIS IN PATIENTS WITH HETEROZYGOSITY FOR FRUCTOSE PHOSPHATE
INTRACELLULAR PHOSPHATE FOR CHONDROCALCINOSIS, ARTHRITIS, OSTEOPOROSIS
ORAL NICTOTINIC ACID FOR TREATMENT OF LESCH NYHAN PATIENTS
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