L-ARGININE IN CYCLOSPORIN-TREATED KIDNEY TRANSPLANT PATIENTS

L-精氨酸在环孢素治疗的肾移植患者中的作用

• 批准号: 3783503
• 负责人: ROBERT S GASTON
• 金额: --
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3783503
• 关键词: arginine; cyclosporines; drug interactions; drug screening /evaluation; endothelin; human subject; human therapy evaluation; kidney circulation; kidney disorder chemotherapy; kidney function; kidney pharmacology; kidney transplantation; nitric oxide; renal toxin; vasodilators

Nitric oxide is a potent vasodilator, synthesized in endothelial cells from the amino acid, L-arginine. In 6 normal humans and 12 renal allograft recipients, this pilot study has attempted to define the effects of L-arginine infusion on renal circulatory dynamics, particularly in the presence of the immunosuppressive agent, cyclosporine.

一氧化氮是一种有效的血管扩张剂，在内皮细胞中合成 从氨基酸L-精氨酸中提取。 在6例正常人和12例肾 同种异体移植受者，这项初步研究试图定义 L-精氨酸输注对肾循环动力学的影响， 特别是在存在免疫抑制剂的情况下， 环孢菌素