Improving the accuracy of X-ray absorptiometry imaging measurements of bone mineral density for the diagnosis and treatment of osteoporosis

提高 X 射线骨密度成像测量的准确性，用于骨质疏松症的诊断和治疗

• 批准号: 131753
• 金额: $ 15.25万
• 依托单位: KROMEK GROUP PLC
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=131753
• 关键词: Improving; accuracy; ray; absorptiometry; imaging

Dual-Energy X-ray Absorptiometry (DXA) imaging is currently the gold standard method for the diagnosis and treatment of osteoporosis. However, DXA measurements of bone mineral density (BMD) are affected by significant errors due to the variable lean and fat composition of the soft tissue surrounding bone. These errors lead to the frequent misdiagnosis of osteoporosis and failure to properly target treatments on the patients most in need.Kromek and King's College London intend to develop innovative algorithms to unlock the extra information captured by DEXA's multispectral detectors but currently not utilised by the outdated methods. This will see a step change in the reduction in noise of the BMD measure, making a breakthrough in the diagnosis and treatment of osteoporosis.The project will start by defining the requirements of the imaging system, followed by computer simulations which will develop and test the methods. A simple hardware system will be built to prove the real-life feasibility of the system, verified by a world-leading expert on bone densitometry..

双能x线吸收仪（DXA）成像是目前诊断和治疗骨质疏松症的金标准方法。然而，骨密度（BMD）的DXA测量受到显著误差的影响，这是由于骨周围软组织的瘦肉和脂肪组成的变化。这些错误导致骨质疏松症的频繁误诊，并不能正确地针对最需要的患者进行治疗。克罗梅克和伦敦国王学院打算开发创新的算法，以解锁DEXA多光谱探测器捕获的额外信息，这些信息目前还没有被过时的方法所利用。这将使BMD测量的降噪程度发生阶级性变化，在骨质疏松症的诊断和治疗方面取得突破。该项目将首先定义成像系统的要求，然后进行计算机模拟，开发和测试这些方法。将建立一个简单的硬件系统，以证明该系统在现实生活中的可行性，由世界领先的骨密度测量专家验证。