LIGHT-ROP

据推测，极早产儿的眼睛光线会减少， 婴儿可能是预防早产儿视网膜病变(ROP)的有效方法。 早产儿眼部使用减光剂的以往报道 婴儿预防ROP产生了相互矛盾的结果。在这 研究称，出生时体重低于1251克的婴儿将有可能 出生后24小时内随机选择佩戴97%中性护目镜 密度过滤直到胎龄31周或4周后- 出生年龄(以较长者为准)，或没有特殊的光照手段 减量(对照组)。眼睛检查将按规定的时间表进行 直到达到任何ROP或视网膜的完全血管化。这个 这项研究的主要目标将是确定光是否 减少ROP会降低ROP的发生率。完整的描述 LIGH=ROP研究的实验设计和科学目标出现了 在所附的《程序手册》中。因为这是一项可行性研究 我们将只能评估统计趋势，而不能回答 明确地问一问。 除了概括地介绍Light-ROP研究之外，该应用程序还 用于资助研究总部、研究中心(布法罗和 达拉斯)和协调中心(休斯顿)。

It is hypothesized that light reduction to the eyes of extremely preterm, infants may be effective in preventing Retinopathy of Prematurity (ROP). Previous reports on the use of light reduction to the eyes of preterm infants for prevention of ROP have produced conflicting results. In this study, infants weighing less than 1251 grams at birth will be prospectively randomized within 24 hours of birth to wear goggles containing 97% neutral density filters until 31 weeks of gestational age (GA) or 4 weeks post- natal age (whichever is longer), or to have no extraordinary means of light reduction (control group). Eyes will be examined on a prescribed schedule until any ROP or full vascularization of the retina is achieved. The primary objective of this study will be to determine whether or not light reduction will decrease the incidence of ROP. The complete description of the experimental design and scientific goals of the LIGHT=ROP Study appear in the attached Manual of Procedures. Because this is a feasibility study we will only be able to evaluate statistical trends, not answer the question definitively. In addition to presenting the LIGHT-ROP Study in general, this application is for funding of the study headquarters, study centers (Buffalo and Dallas) and the coordinating center (Houston).