Integrative metabolomics of bronchopulmonary dysplasia in extremely low gestational age infants
极低胎龄儿支气管肺发育不良的综合代谢组学
基本信息
- 批准号:10571837
- 负责人:
- 金额:$ 40.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AcuteAdrenal Cortex HormonesAfrican AmericanAgeBiochemicalBiochemical PathwayBiologicalBiological MarkersBlack AmericanBronchopulmonary DysplasiaCessation of lifeChildhoodCohort StudiesDevelopmentDiagnosisDiseaseEarly DiagnosisEarly identificationEarly treatmentEnvironmentEnvironmental ExposureEthnic OriginEthnic PopulationExtremely low gestational age newbornGeneticGenetic ProcessesGenetic studyGenomicsGestational AgeGoalsGrowthHealthInfantInterventionKnowledgeLiquid substanceLungLung diseasesMeasuresMedicalMolecularMothersOutcomePathogenesisPathway interactionsPatient Self-ReportPharmaceutical PreparationsPhysiological ProcessesPhysiologyPopulationPopulation HeterogeneityPostnatal respiratory distressPregnancyPremature InfantPreventionProcessQuantitative Trait LociRaceResourcesRisk AssessmentRoleSeveritiesSumTestingTherapeuticTimeTracheaUrineVariantaspiratebiomarker developmentclinical biomarkerscohortdisorder riskearly detection biomarkersempowermentethnic differencegenome wide association studygenomic locushigh riskhigh risk populationimprovedinfant outcomeinhaled nitric oxideinsightknowledge baselong-term sequelaelung developmentmetabolic profilemetabolomemetabolomicsmultiple omicsnovelnovel markernutritionpostnatalprematurepreventprogramsracial differenceracial diversityracial populationrespiratoryrespiratory morbidityresponsesocialsupplemental oxygensurfactanttargeted treatmenttime useurinary
项目摘要
PROJECT SUMMARY/ABSTRACT
Bronchopulmonary dysplasia (BPD) in preterm infants is a common and often severe lung disease with long
term sequelae. Rates of BPD vary between racial/ethnic groups, which may be due to differences in genetic
ancestry or environment factors. Changes in the biochemical composition of biofluids (the metabolome) reflect
the sum of both genetics and the environment, and thus characterizing these changes offers a broader view of
the disease process as compared to genetic studies alone. Our goal is to increase our understanding of the
biological basis of BPD and response to interventions in genetically diverse preterm infants at high risk of dis-
ease. We hypothesize that there are temporal changes in the urinary and tracheal aspirate (TA) metabolome of
the premature infant that are associated with respiratory outcomes and interventions, and that some of these
changes vary by infant genetic ancestry. We will test our hypothesis with three specific aims. Specific Aim 1:
Longitudinal characterization of the urinary and lung fluid metabolome of preterm infants. We will
measure longitudinal changes in metabolic profiles of urine and tracheal aspirates in two cohorts of preterm
infants at high risk of BPD from three racial/ethnic groups. We will identify changes in the metabolome of
infants that are associated with respiratory status (diagnosis of BPD and later respiratory outcomes) and inter-
ventions (e.g. type of nutrition, iNO therapy, corticosteroids, and other medications). Results from this aim will
provide new information on the biofluid metabolome of preterm infants, biomarkers of disease and response to
interventions, and insight into postnatal lung development and disease pathogenesis. Specific Aim 2:
Examine the contribution of genetic ancestry, race and ethnicity on longitudinal changes in the biofluid
metabolome of preterm infants. We will investigate the contribution of genetic ancestry and maternal self-
reported race/ethnicity on temporal changes in the biofluid metabolome of premature infants. We will identify
metabolites and pathways whose trajectories are associated with genomic ancestry independent of maternal
race/ethnicity, and identify those under stronger genetic vs. social/ environmental determination. Results from
this aim will provide new information as to the role of genetics on the biofluid metabolome of preterm infants as
it relates to racial/ethnic differences in BPD and response to interventions. Specific Aim 3: Integrate genomic
and metabolomic studies of BPD. We will identify novel metabolite quantitative trait loci (mQTL) in high risk
preterm infants using a two-step approach that leverages variation in local genetic ancestry, and develop a
resource to empower multi-omic studies of BPD. We will then combine this information with a genome-wide
association study (GWAS) of BPD by integrating metabolomic and genomic associations in the same infants to
identify novel genetic loci and biochemical pathways involved in the development and pathogenesis of BPD.
Relevance: Results from this proposal will advance our understanding of disease pathogenesis in high risk
preterm infants, and support the development of biomarkers and precision-targeted therapies.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PHILIP L. BALLARD其他文献
PHILIP L. BALLARD的其他文献
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{{ truncateString('PHILIP L. BALLARD', 18)}}的其他基金
Integrative metabolomics of bronchopulmonary dysplasia in extremely low gestational age infants
极低胎龄儿支气管肺发育不良的综合代谢组学
- 批准号:
10211037 - 财政年份:2021
- 资助金额:
$ 40.38万 - 项目类别:
Integrative metabolomics of bronchopulmonary dysplasia in extremely low gestational age infants
极低胎龄儿支气管肺发育不良的综合代谢组学
- 批准号:
10396118 - 财政年份:2021
- 资助金额:
$ 40.38万 - 项目类别:
Proteomic Profile Associated with Chronic Lung Disease of Premature Infants
与早产儿慢性肺病相关的蛋白质组学特征
- 批准号:
9144847 - 财政年份:2015
- 资助金额:
$ 40.38万 - 项目类别:
Proteomic Profile Associated with Chronic Lung Disease of Premature Infants
与早产儿慢性肺病相关的蛋白质组学特征
- 批准号:
8996845 - 财政年份:2015
- 资助金额:
$ 40.38万 - 项目类别:
EXPRESSION AND FUNCTION OF CEACAM6 IN THE ALVEOLUS
CEACAM6 在肺泡中的表达和功能
- 批准号:
8054534 - 财政年份:2011
- 资助金额:
$ 40.38万 - 项目类别:
UCSF Clinical Research Center for Prematurity and Respiratory Outcomes Program
加州大学旧金山分校早产和呼吸结果临床研究中心项目
- 批准号:
8068781 - 财政年份:2010
- 资助金额:
$ 40.38万 - 项目类别:
UCSF Clinical Research Center for Prematurity and Respiratory Outcomes Program
加州大学旧金山分校早产和呼吸结果临床研究中心项目
- 批准号:
8281489 - 财政年份:2010
- 资助金额:
$ 40.38万 - 项目类别:
UCSF Clinical Research Center for Prematurity and Respiratory Outcomes Program
加州大学旧金山分校早产和呼吸结果临床研究中心项目
- 批准号:
8662299 - 财政年份:2010
- 资助金额:
$ 40.38万 - 项目类别:
UCSF Clinical Research Center for Prematurity and Respiratory Outcomes Program
加州大学旧金山分校早产和呼吸结果临床研究中心项目
- 批准号:
7868513 - 财政年份:2010
- 资助金额:
$ 40.38万 - 项目类别:
UCSF Clinical Research Center for Prematurity and Respiratory Outcomes Program
加州大学旧金山分校早产和呼吸结果临床研究中心项目
- 批准号:
8464208 - 财政年份:2010
- 资助金额:
$ 40.38万 - 项目类别:














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