Clostridial on purpose acetone (COPA)

全球对丙酮有很大的需求，用于溶剂和生产重要的化学品和材料，包括透明塑料，如甲基丙烯酸甲酯（MMA）。丙酮目前是由石油化学品丙烯和苯反应生产的，因此其价格不稳定，而且该工艺是不可持续的。GBL是梭菌（非致病性）发酵生产溶剂正丁醇的专家，正丁醇会产生一些丙酮作为副产品。我们（GBL和MMA生产商Lucite）进行了一项InnovateUK业务研究，以调查仅生产丙酮的工艺的潜力，并确定这在经济和技术上是可行的。我们希望利用我们在梭菌生物学方面的专业知识来开发一种具有商业过程所需的高产丙酮的梭菌菌株。璐彩特将探讨有关使用生物丙酮生产生物甲基丙烯酸甲酯的事宜。

There is large global demand for acetone for use as a solvent and in production of important chemicals and materials including transparent plastics such as methyl methacrylate (MMA). Acetone is currently produced by reacting petro-chemicals propylene and benzene, hence its price is volatile and the process is unsustainable. GBL are experts in clostridial (non-pathogenic) fermentation for production of the solvent n-butanol, which generates some acetone as a co-product. We (GBL and MMA-producer Lucite) undertook an InnovateUK business study to investigate potential for a process making solely acetone, and determined that this would be economically and technologically feasible. We want to use our expertise in clostridial biology to develop a strain of clostridia having high yield of acetone, necessary for the commercial process. Lucite will explore matters relating to use of bio-acetone for bio-MMA production.