EXERCISE IN NON-INSULIN DEPENDENT MEN AND WOMEN

非胰岛素依赖性男性和女性的锻炼

• 批准号: 3027776
• 负责人: LAURETTA T QUINN
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-10-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3027776
• 关键词: aerobic exercise; basal metabolism; blood lipoprotein metabolism; circadian rhythms; glucose metabolism; hemostasis; human subject; lipid metabolism; noninsulin dependent diabetes mellitus; quality of life

Non-insulin dependent diabetes mellitus (NIDDM) affects 11 millions individuals in the United States and is associated with a number of debilitating chronic complications thought to be related to alterations in glucose, lipid and lipoprotein metabolism and hemostasis. These complications signify an enormous cost both physiologically and psychologically on those affected, impacting their quality of life in many ways. Exercise has been shown to improve glucose, lipid and lipoprotein metabolism, hemostasis and quality of life in normal subjects. Exercise has the potential to improve these variables in NIDDM subjects, although this issue has been systematically evaluated in few studies. This study will examine the effects of four weeks of three times weekly aerobic physical training at 65% VO2 max in a group of 15 NIDDM diet stabilized and weight maintained men and women on glucose metabolism, lipid and lipoprotein metabolism, hemostasis and quality of life. A VO2 max determination will be made 48 hours prior to and 48 hours after the four week exercise training period. Indices of lipid and lipoprotein (plasma lipids, apolipoproteins, lipoprotein surface and core lipid metabolism) will be made 72 hours prior to and 72 hours after the four week exercise training period in the fasting resting basal state. Indices of hemostasis metabolism (fibrinogen and fibrinolysis) will be measured 48 hours prior to and after the four week exercise training period in both the fasting resting basal state and immediately post VO2 max determination. Indices of glucose metabolism (serum fructosamine and an intravenous glucose tolerance test) will be made immediately after the initial VO2 max determination and immediately after the final VO2 max determination. Quality of life will be assessed on the same day as the lipid measurements. All measurements will be performed in the morning to control for diurnal variation. The measurements of glucose, lipids and lipoproteins, and hemostasis will be compared pre and post exercise training using a paired T-test while the quality of life data will be analyzed using non-parametric procedure, the McNemar Test.

非胰岛素依赖型糖尿病（NIDDM）影响1100万人 在美国的个人，并与一些 使人衰弱的慢性并发症被认为与 葡萄糖、脂质和脂蛋白代谢和止血。 这些 并发症意味着巨大的生理和 心理上对那些受影响，影响他们的生活质量，在许多 的方式 运动已被证明可以改善血糖、血脂和脂蛋白 代谢、止血和正常受试者的生活质量。 行使 有可能改善NIDDM受试者的这些变量，尽管 这一问题已在少数研究中得到系统评价。 本研究 将检查每周三次有氧运动持续四周的效果 在15名NIDDM饮食稳定的患者中进行65%VO2 max的体育训练， 维持体重的男性和女性对葡萄糖代谢、脂质和 脂蛋白代谢、止血和生活质量。 A VO2 max 将在四个小时之前和之后的48小时内进行确定 一周的锻炼时间。 血脂和脂蛋白（血浆）指标 脂质、载脂蛋白、脂蛋白表面和核心脂质代谢） 将在为期四周的演习前72小时和演习后72小时进行 在空腹静息基础状态下进行训练。 止血指数 代谢（纤维蛋白原和纤维蛋白溶解）将在给药前48小时测量。 在禁食和禁食的四周运动训练期后， 静息基础状态和最大摄氧量测定后即刻。 指标 葡萄糖代谢（血清果糖胺和静脉葡萄糖耐量 测试）将在初始VO2 max测定后立即进行， 在最后一次VO2 max测定后立即进行。 生活质量将是 在测量血脂的同一天进行评估。 所有测量将 在早晨进行，以控制昼夜变化。 的 血糖、血脂和脂蛋白的测量，以及止血， 使用配对T检验比较了运动训练前后， 生活质量数据将使用非参数程序进行分析， McNemar检验。