EXERCISE IN NON-INSULIN DEPENDENT MEN AND WOMEN

非胰岛素依赖型糖尿病(NIDDM)影响1100万 在美国的个人，并与许多 衰弱的慢性并发症被认为与心脏功能的改变有关 葡萄糖、脂类和脂蛋白代谢与止血。这些 并发症意味着巨大的生理和心理代价 从心理上影响那些受影响的人，影响他们的生活质量在许多 方式。运动已被证明可以改善血糖、血脂和脂蛋白 正常人的代谢、止血和生活质量。锻炼 有可能改善NIDDM受试者的这些变量，尽管 这个问题在很少的研究中得到了系统的评估。本研究 将检查四周每周三次有氧运动的效果 在15名NIDDM饮食组中，以65%最大摄氧量进行的体育训练稳定并 维持体重的男性和女性对糖代谢、血脂和 脂蛋白代谢、止血和生活质量。最大摄氧量 将在四个小时之前和之后的48小时内做出决定 每周锻炼训练期。血脂和脂蛋白指标(血浆 脂类、载脂蛋白、脂蛋白表面和核心脂代谢) 将在四周演习前72小时和之后72小时进行 训练期处于禁食休息的基础状态。止血指标 新陈代谢(纤维蛋白原和纤溶)将在48小时前进行测量 并在经过四周的运动训练期后禁食 静息基础状态和最大摄氧量测定后即刻。索引： 葡萄糖代谢(血清果糖胺和静脉注射糖耐量 测试)将在初始最大摄氧量测定之后立即进行，并且 紧接在最大摄氧量最终测定之后。生活质量将是 在进行血脂测量的同一天进行评估。所有测量结果都将 在早上进行，以控制昼夜变化。这个 血糖、血脂和脂蛋白的测量以及止血将是 使用配对T检验比较运动前后的训练，而 生活质量数据将使用非参数程序进行分析， 麦克内马尔测试。

Non-insulin dependent diabetes mellitus (NIDDM) affects 11 millions individuals in the United States and is associated with a number of debilitating chronic complications thought to be related to alterations in glucose, lipid and lipoprotein metabolism and hemostasis. These complications signify an enormous cost both physiologically and psychologically on those affected, impacting their quality of life in many ways. Exercise has been shown to improve glucose, lipid and lipoprotein metabolism, hemostasis and quality of life in normal subjects. Exercise has the potential to improve these variables in NIDDM subjects, although this issue has been systematically evaluated in few studies. This study will examine the effects of four weeks of three times weekly aerobic physical training at 65% VO2 max in a group of 15 NIDDM diet stabilized and weight maintained men and women on glucose metabolism, lipid and lipoprotein metabolism, hemostasis and quality of life. A VO2 max determination will be made 48 hours prior to and 48 hours after the four week exercise training period. Indices of lipid and lipoprotein (plasma lipids, apolipoproteins, lipoprotein surface and core lipid metabolism) will be made 72 hours prior to and 72 hours after the four week exercise training period in the fasting resting basal state. Indices of hemostasis metabolism (fibrinogen and fibrinolysis) will be measured 48 hours prior to and after the four week exercise training period in both the fasting resting basal state and immediately post VO2 max determination. Indices of glucose metabolism (serum fructosamine and an intravenous glucose tolerance test) will be made immediately after the initial VO2 max determination and immediately after the final VO2 max determination. Quality of life will be assessed on the same day as the lipid measurements. All measurements will be performed in the morning to control for diurnal variation. The measurements of glucose, lipids and lipoproteins, and hemostasis will be compared pre and post exercise training using a paired T-test while the quality of life data will be analyzed using non-parametric procedure, the McNemar Test.