Methods of Microbial Control in the Clostridial ABE Fermentation Process (MiCON)

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Green Biologics is an industrial biotech company, currently re-commercialising the clostridial ABEfermentation process for the production of n-butanol and acetone from renewable and sustainablefeedstocks. There are many challenges inherent in this commercialisation process, not just with thecomplexities of engineering and process design but also with ensuring the clostridial strains used exhibitrobust phenotypes such as resistance to phage infections and ability to out compete microbesindigenous to the plant environment. This project aims to use an innovative and environmentallyreponsible alternative approach to the ‘easy fix’ solution of using antibiotics by instead taking advantageof bacteriocins: small peptides produced by a number of bacterial strains to destroy competingmicrobes in an environmental space.