Methods of Microbial Control in the Clostridial ABE Fermentation Process (MiCON)

梭菌 ABE 发酵过程 (MiCON) 中的微生物控制方法

• 批准号: 132324
• 金额: $ 13.57万
• 依托单位: GREEN BIOLOGICS LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=132324
• 关键词: Methods; Microbial; Control; Clostridial; ABE

Green Biologics is an industrial biotech company, currently re-commercialising the clostridial ABEfermentation process for the production of n-butanol and acetone from renewable and sustainablefeedstocks. There are many challenges inherent in this commercialisation process, not just with thecomplexities of engineering and process design but also with ensuring the clostridial strains used exhibitrobust phenotypes such as resistance to phage infections and ability to out compete microbesindigenous to the plant environment. This project aims to use an innovative and environmentallyreponsible alternative approach to the ‘easy fix’ solution of using antibiotics by instead taking advantageof bacteriocins: small peptides produced by a number of bacterial strains to destroy competingmicrobes in an environmental space.

Green Biologics是一家工业生物技术公司，目前正在将梭状芽胞杆菌ABE发酵工艺重新商业化，以可再生和可持续的原料生产正丁醇和丙酮。在这一商业化过程中存在许多固有的挑战，不仅是工程和工艺设计的复杂性，而且还涉及确保所使用的梭状芽胞杆菌表现出强大的表型，如对噬菌体感染的抵抗力和击败植物环境中固有的竞争微生物的能力。该项目旨在使用一种创新的、对环境负责的替代方法，通过利用细菌素来替代使用抗生素这一容易修复的解决方案。细菌素是由许多细菌菌株产生的小肽，可以在环境空间中摧毁竞争对手的微生物。