Cell-Sort MultiTool: a Novel Platform for Bacterial Single-Cell Analysis

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This project aims to advance molecular understanding of antibiotic resistance in bacterial populations at the single-cell level, using an innovative approach integrating microfluidics, microscopy and genomics. The study of individual bacterial cell genetics is essential to provide fundamental insights into heterogeneous resistance, an important component of resistance development. Expected outcomes include a new platform technology for high-throughput multiplexed screening and improved knowledge of bacterial heterogeneity, informing antibiotic usage. This interdisciplinary project should yield significant benefits in society and economy by reducing healthcare costs, boosting health for Australians and commercialising advanced technologies.