On the Hunt: Boosting Productivity of Cell Factories by Advanced Searches

寻找中：通过高级搜索提高细胞工厂的生产力

• 批准号: DP240100795
• 负责人: A/Prof Ming Li
• 金额: $ 38.28万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100795
• 关键词: Hunt; Boosting; Productivity; Cell; Factories

This project aims to advance our fundamental understanding of molecular mechanisms underlying protein secretion in yeast, an industrial workhorse and a model organism. It will develop a unique multifaceted research platform to identify and analyse superior yeast strains with the desired traits at the single-cell level. Expected outcomes include a new analytical tool for high-throughput strain analysis and advanced knowledge of yeast molecular biology that can be applied to improve cell factories for the next generation of fuels, food and pharmaceuticals. This will provide significant economic and social benefits by boosting biotech industry growth, facilitating the transition to a sustainable society and improving Australia’s biosecurity.

该项目旨在促进我们对酵母蛋白质分泌的分子机制的基本理解，酵母是一种工业主力和模式生物。它将开发一个独特的多方面的研究平台，以确定和分析上级酵母菌株与所需的性状在单细胞水平。预期成果包括用于高通量菌株分析的新分析工具和酵母分子生物学的先进知识，这些知识可用于改进下一代燃料、食品和药品的细胞工厂。这将通过促进生物技术产业的增长、促进向可持续社会的过渡和改善澳大利亚的生物安全来提供显着的经济和社会效益。