Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches

流体流动扰动整合素激活：力学生物学方法

• 批准号: DP200101970
• 负责人: A/Prof Lining (Arnold) Ju
• 金额: $ 32.92万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-12-18 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101970
• 关键词: Integrin; Activation; Fluid; Flow; Disturbance

Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.

了解细胞如何感知和响应动态血流等机械环境是机械生物学新兴领域的一个基本问题。该项目开发了新的生物力学工程方法，以确定流体流动障碍，血小板凝血和整合素受体的机械敏感信号转导机制之间的关键相互关系-最重要的机械传感器涉及细胞粘附，迁移，生长和存活。具体而言，它集成了国内独特的尖端技术，包括单分子力探针，微粒图像测速，微流体和分子动力学模拟，超分辨率和3D体积成像模式。