MITOCHONDRIAL DNA POLYMERASE--MECHANISM AND STRUCTURE
MITOCHONDRIAL DNA POLYMERASE--MECHANISM AND STRUCTURE
批准号:
2183051
负责人:
LAURIE SIMON KAGUNI
金额:
$14.92万
依托单位国家:
美国
项目类别:
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-07-01 至 1996-06-30
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The long term objective of the proposed work is the elucidation
of the mechanism of DNA replication in animal mitochondria. This may be
accomplished when purified enzymes are reconstituted in vitro to yield
replication complexes capable of initiation and elongation of DNA
synthesis. The studies will provide the framework for research to
determine the regulation of these processes as they occur in vivo.
The current proposal focuses on the major replicative enzyme in
mitochondria, DNA polymerase gamma. A combined approach involving
biochemical, immunological and molecular biological methods will be
employed to undertake mechanistic and structure-function analysis of the
mitochonchial DNA polymerase and to done and overproduce its two
subunits. Secondary goals involve isolation of a mitochondrial RNA
polymerase / DNA primase and examination of the co-ordination of RNA
priming and DNA synthesis on mitochondrial DNA templates.
The control of animal cell reproduction during normal
development, and the loss of control during cancerous development, is of
central importance in the processes of human growth, aging, and disease.
Prior to every cell division, the DNA complement of each cell is
duplicated. Because DNA replication and cell division are tightly
coupled, an understanding of the mechanisms of DNA replication
functioning in animal cells is essential to our understanding of these
basic processes.
Mitochondrial biogenesis proceeds in parallel with cell
proliferation, but it is neither tightly coupled to mitochondrial DNA
replication nor to the cell cycle. Nevertheless, because both the DNA
content of the mitochondrion and the number of mitochondria in cells
remain relatively constant, specific regulatory mechanisms are likely
required to couple mitochondrial DNA replication and biogenesis to
nuclear DNA replication and cell division. A detailed analysis of the
key enzyme involved in mitochondrial DNA replication, gamma polymerase,
will represent a major contribution toward an eventual understanding of
mitochondrial biogenesis.
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MITOCHONDRIAL DNA POLYMERASE: MECHANISM AND STRUCTURE
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批准号:7933151
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项目类别:
-
资助金额:$25.92万
-
财政年份:2009
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA REPLICATION FIDELITY & CARDIAC DISEASE
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批准号:2771634
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项目类别:
-
资助金额:$11.03万
-
财政年份:1997
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA REPLICATION FIDELITY & CARDIAC DISEASE
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批准号:2469853
-
项目类别:
-
资助金额:$11.03万
-
财政年份:1997
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA REPLICATION FIDELITY & CARDIAC DISEASE
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批准号:6056484
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项目类别:
-
资助金额:$11.03万
-
财政年份:1997
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE: MECHANISM AND STRUCTURE
-
批准号:6625082
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项目类别:
-
资助金额:$26.73万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
Mitochondrial DNA Replisome: Mechanism, Structure and Physiology
-
批准号:8061977
-
项目类别:
-
资助金额:$33.43万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE--MECHANISM AND STRUCTURE
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批准号:3304709
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项目类别:
-
资助金额:$15.06万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE: MECHANISM AND STRUCTURE
-
批准号:6476519
-
项目类别:
-
资助金额:$26.73万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE--MECHANISM AND STRUCTURE
-
批准号:3304710
-
项目类别:
-
资助金额:$14.13万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE--MECHANISM AND STRUCTURE
-
批准号:2838575
-
项目类别:
-
资助金额:$18.78万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE: MECHANISM AND STRUCTURE
-
批准号:6287220
-
项目类别:
-
资助金额:$26.68万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE: MECHANISM AND STRUCTURE
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批准号:6976893
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项目类别:
-
资助金额:$29.52万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE: MECHANISM AND STRUCTURE
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批准号:7123414
-
项目类别:
-
资助金额:$28.87万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE--MECHANISM AND STRUCTURE
-
批准号:2608921
-
项目类别:
-
资助金额:$18.36万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE--MECHANISM AND STRUCTURE
-
批准号:3304711
-
项目类别:
-
资助金额:$14.15万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
Mitochondrial DNA Replisome: Mechanism, Structure and Physiology
-
批准号:8468712
-
项目类别:
-
资助金额:$32.32万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
Mitochondrial DNA Replisome: Mechanism, Structure and Physiology
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批准号:8245766
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项目类别:
-
资助金额:$33.45万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
Mitochondrial DNA Replisome: Mechanism, Structure and Physiology
-
批准号:7889371
-
项目类别:
-
资助金额:$33.77万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE: MECHANISM AND STRUCTURE
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批准号:7283769
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项目类别:
-
资助金额:$27.99万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
MITOCHONDRIAL DNA POLYMERASE: MECHANISM AND STRUCTURE
-
批准号:7491239
-
项目类别:
-
资助金额:$27.94万
-
财政年份:1991
-
负责人:LAURIE SIMON KAGUNI
-
依托单位:
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