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Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase

Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase
DNA损伤对线粒体RNA聚合酶转录反应的影响
批准号:
22510060
负责人:
KURAOKA Isao
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Mitochondrial RNA polymerase (mtRNAP) catalyzes the synthesis of essential transcripts in mitochondria where reactive oxidative (ROS) species are generated as byproducts. The occurrence of RNA synthesis by mtRNAP at oxidative DNA lesions remains unknown. Purified mtRNAP and a complex of RNA primer/DNA template containing a single DNA lesion were used for in vitro RNA synthesis assays. We show that mtRNAP bypassed the oxidative DNA lesion.
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DOI: 10.4061/2010/701472
发表时间: 2010-01-01
期刊: JOURNAL OF NUCLEIC ACIDS
影响因子: 2.3
作者: [Kashiwagi, Sayo, Kuraoka, Isao, Iwai, Shigenori]
通讯作者: Iwai, Shigenori
New function of human endonuclease V
人核酸内切酶V的新功能
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Horibata K, Saijo M, Bay MN, Lan L, Kuraoka I, Brooks PJ, Honma M, Nohmi T, Yasui A, Tanaka K., Isao Kuraoka, 倉岡 功, Isao Kuraoka, Isao Kuraoka]
通讯作者: Isao Kuraoka
DOI: 10.1111/j.1365-2443.2010.01467.x
发表时间: 2011-01-01
期刊: GENES TO CELLS
影响因子: 2.1
作者: [Horibata, Katsuyoshi, Saijo, Masafumi, Tanaka, Kiyoji]
通讯作者: Tanaka, Kiyoji
Xeroderma p igmentosum group F protein binds to Eg5 and is required for proper mitosis: implicati ons for XP-F and XFE.
着色干皮病 F 组蛋白与 Eg5 结合,是正常有丝分裂所必需的:对 XP-F 和 XFE 的影响。
DOI: --
发表时间: 2012
期刊: Genes Cells
影响因子: 2.1
作者: [Tan LJ, Saijo M, Kuraoka I, Narita T, T akahata C, Iwai S, Tanaka K]
通讯作者: Tanaka K
32
    Analysis of DNA damage avoidance systems by RNA polymerase II on transcription elongation
    海外基金