Rapid point of care test for Group B streptococcus in late pregnancy and onset of labour

妊娠晚期和临产时 B 族链球菌的快速护理点检测

• 批准号: 133055
• 金额: $ 13.13万
• 依托单位: IMSPEX DIAGNOSTICS LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=133055
• 关键词: Rapid; point; care; test; Group

GBS is a common bacterium found in the vagina of about 2 in 10 women in the UK. Being a carrier is not harmful to you, however, many babies come into contact with GBS during labour. The vast majority of babies will suffer no ill effects. However, if GBS is passed from mother to baby at time of the birth, there is a small chance the baby will develop an infection and become seriously ill. There is no screening program available for GBS in the UK and the NHS currently uses a risk factor approach, which means that some women receive antibiotics when they don’t need them. This is because although GBS can be detected by a swab taken in late pregnancy the current testing method used by the NHS is not very reliable when a negative result is found and can take 4 days to get a result. A more accurate result can be obtained by another method, but this is only available privately as it is too expensive. This study will use a new machine called a GC-IMS. Previous work has shown it to be very accurate when testing for GBS and can report the result in less than 10 minutes. If this device were then used in the NHS it could detect GBS as soon as women go into labour and doctors will be able to give antibiotics if necessary, therefor reducing risk to new born babies.

GBS是一种常见的细菌，在英国约有2/10的女性的阴道中发现。作为携带者对你没有害处，然而，许多婴儿在分娩时接触到GBS。绝大多数婴儿不会受到不良影响。然而，如果GBS在出生时从母亲传给婴儿，婴儿患上感染和重病的可能性很小。在英国，没有针对GBS的筛查计划，NHS目前使用风险因素方法，这意味着一些女性在不需要的时候接受抗生素治疗。这是因为，虽然妊娠晚期采集的棉签可以检测出GBS，但NHS目前使用的检测方法在发现阴性结果时并不是很可靠，可能需要4天才能得出结果。可以通过另一种方法获得更准确的结果，但由于成本太高，只能私下获得。这项研究将使用一种名为GC-IMS的新机器。以前的工作表明，它在检测GBS时非常准确，并且可以在不到10分钟的时间内报告结果。如果NHS随后使用这种设备，它可以在妇女分娩时立即检测出GBS，如果必要的话，医生将能够给他们抗生素，从而降低新生儿的风险。