CONCEPTUAL ASPECTS OF THE PROTEIN FOLDING PROBLEM

蛋白质折叠问题的概念方面

• 批准号: 3303730
• 负责人: Peter Guy Wolynes
• 金额: $ 10.66万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3303730
• 关键词: amorphous solid; computer assisted sequence analysis; computer simulation; mathematical model; mathematics; molecular dynamics; molecular energy level; myoglobin; pancreas hormone; phase change; physical model; protein folding; protein structure; rubredoxins; thermodynamics

The proposed work is concerned with exploring how some new ideas from condensed matter physics, the theory of spin glasses, may be used to illuminate our understanding of protein folding. Spin glasses are substances which have many disordered states. Folding is the last step in the process of uncoding genetic information into functional molecules. The understanding of folding could allow more rapid advances in genetic engineering. Defects of folding may be involved in some human diseases. The new ideas have to do with trying to use spin glass theory to understand the role of intermediates and misfolded structures in the folding process and how to avoid them in computer algorithms for predicting protein structure from sequence. Several analytical studies of the thermodynamics and dynamics of spin glass models of protein folding are proposed. Computer simulations are also planned that will use the analytical information to optimize folding algorithms.

提议的工作是关于探索如何从一些新的想法