A novel instrument for the analysis of urine for the nonA novel instrument for the analysis of urine for the non-invasive detection of bladder cancer-invasive detection of bladder cancer

一种新型尿液分析仪，用于非侵入性检测膀胱癌-侵入性检测膀胱癌

• 批准号: 133113
• 金额: $ 8.91万
• 依托单位: PARAYTEC LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=133113
• 关键词: novel; instrument; analysis; urine; nonA

Can we detect and monitor bladder cancer with a urine test? For many patients with bladder cancer (BC), their cancer comes back after treatment and so they have to be regularly checked. These patients are checked with a cystoscope. This is a long thin flexible tube with a light and a camera at the end that is inserted into the urethra (the tube that carries urine out of the body) and up into the bladder. The camera shows the inside of the bladder and the doctor can make a diagnosis. This method of diagnosis (cystoscopy) can be uncomfortable for the patient and is expensive to the NHS. This project aims to find out if a new laboratory method could be used instead. The test needs to be able to tell the difference between tumour cells and other things in the urine like regular cells shed into the urine by the normal action of the bladder and germs that are not due to these cancers. To do this we will shine UV and visual light at samples which mimic urine samples and take a video of the samples flowing. We have a new better way of doing this that will give us sharper images of the cells, especially in the UV light, and allow us to look at bigger samples up to 50 ml. Computer software will then take the data from the instrument and tell us information about the cells. We hope to be able to tell the difference between tumour cells, normal cells and blood cells and reduce the number of cystoscopies that patients need in future.

我们可以通过尿液检查来检测和监测膀胱癌吗？对于许多膀胱癌 (BC) 患者来说，他们的癌症在治疗后会复发，因此必须定期检查。使用膀胱镜检查这些患者。这是一根细长的柔性管，末端有一个灯和一个摄像头，插入尿道（将尿液排出体外的管道）并向上进入膀胱。摄像头显示膀胱内部，医生可以做出诊断。这种诊断方法（膀胱镜检查）可能会让患者感到不舒服，并且 NHS 的费用昂贵。该项目旨在找出是否可以使用新的实验室方法来代替。该测试需要能够区分肿瘤细胞和尿液中的其他物质，例如通过膀胱正常活动流入尿液的常规细胞和并非由这些癌症引起的细菌。为此，我们将用紫外线和可见光照射模拟尿液样本的样本，并拍摄样本流动的视频。我们有一种新的更好的方法来做到这一点，这将为我们提供更清晰的细胞图像，尤其是在紫外光下，并允许我们观察高达 50 毫升的更大样本。然后计算机软件将从仪器中获取数据并告诉我们有关细胞的信息。我们希望能够区分肿瘤细胞、正常细胞和血细胞，并减少患者未来需要进行膀胱镜检查的次数。