Angle Sensitive MRI for Musculoskeletal Diagnostics

用于肌肉骨骼诊断的角度敏感 MRI

• 批准号: 133483
• 金额: $ 20.36万
• 依托单位: MR SOLUTIONS LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=133483
• 关键词: Angle; Sensitive; MRI; Musculoskeletal; Diagnostics

"Tissues including ligaments and tendons usually produce little or no signal in normal Magnetic Resonance Imaging (MRI). Consequently they usually appear black, while any bright areas are possible artefacts or possible signs of disease. It is largely this anomaly that leads to further investigation using surgical procedures. Researchers at Imperial College have developed an entirely new type of MRI scanner, which offers the potential to obtain new information which may be important clinically and to provide new methods for diagnosing disease or injury in joints, which are non-invasive and safe, while providing information that cannot be easily obtained by other means. This scanner is also much cheaper, very compact and easier to install than those normally found in hospitals.In the proposed project we aim to demonstrate the feasibility of this approach and to provide the evidence needed to facilitate further medical research. We will upgrade the existing prototype MRI in our laboratory with professional electronics and software so that it is suitable for clinical use. Various detailed improvements in the scanner hardware and image processing software will be carried out. Imaging studies will involve the use of phantoms, representative animal tissue samples available in our laboratories, as well as healthy volunteers. The MRI images will be analysed in collaboration with medical specialists in order to establish how best to use the new MRI capabilities and demonstrate its clinical value."

“包括韧带和肌腱在内的组织在正常磁共振成像 (MRI) 中通常产生很少或没有信号。因此，它们通常呈黑色，而任何明亮区域都可能是伪影或可能的疾病迹象。很大程度上正是这种异常导致使用外科手术进行进一步调查。帝国理工学院的研究人员开发了一种全新类型的 MRI 扫描仪，它提供了获得可能在临床上重要的新信息的潜力，并为治疗提供了新方法。 以非侵入性且安全的方式诊断关节疾病或损伤，同时提供通过其他方式无法轻易获得的信息。这种扫描仪也比医院中常见的扫描仪便宜得多、非常紧凑且易于安装。在拟议的项目中，我们的目标是证明这种方法的可行性，并提供促进进一步医学研究所需的证据。我们将用专业的电子设备和软件对实验室现有的 MRI 原型机进行升级，使其 适合临床使用。扫描仪硬件和图像处理软件将进行各种细节改进。成像研究将涉及使用模型、我们实验室提供的代表性动物组织样本以及健康志愿者。我们将与医学专家合作对 MRI 图像进行分析，以确定如何最好地利用新的 MRI 功能并展示其临床价值。”