DETERMINANTS OF THE DISEASE ACTIVITY AND PROGNOSIS FOR INTERSTITIAL LUNG DISEASE

该项目的总体假设是，放射学，生理学， 或生物学措施能够在一定程度上识别间质性肺病， 早期阶段，能够确定疾病的总体活动， 能够预测肺部疾病的发展过程 未来五 研究人员打算继续评估临床 这些生物标志物用于评估间质性肺病的效用。 的 该项目的目标是确定决定 间质性肺患者的疾病活动性和预后 疾病 尽管申请人和其他调查人员发现 各种疾病测量之间的关联，临床 用于评估间质性肺疾病的生物标志物的效用尚未被 批判性地评价。 虽然项目I不是为了研究 间质性肺疾病的发病机制， 这些疾病现在可以作为这些临床研究的生物标志物。 此外，项目I建议的研究结果可能会加强和 重新指导本SCOR中其他项目中概述的病原学研究 程序. 研究人员将研究和比较四种类型的间质性肺 疾病-特发性肺纤维化（IPF）、石棉肺、间质性 与类风湿性关节炎相关的纤维化（RA-ILD）和结节病。 其中三种疾病（IPF、石棉肺和RA-ILD）具有相似的 放射学和组织学表现。 相反，结节病表现出 影像学和组织学发现明显不同。 虽然所有 这些疾病涉及肺的结节、解剖学上的 这些疾病的分布，如高分辨率检测到的 计算机断层扫描（HRCT）扫描，是绝对不同的-结节病 主要累及气道和支气管周围实质， 三种肺部疾病主要涉及肺实质。 但在 所有这些疾病，高分辨率CT（HRCT）扫描能够 识别肺部受累的异质性区域。 病因 与这四种疾病相关的预后也很明显 不同. 这些差异和相似之处将允许评估 疾病类别内和疾病类别之间的风险因素和预测因素。 制定了具体目标，以进一步追求和扩大 正在进行的间质性肺病研究项目， 爱荷华州。

The overall hypothesis of this project is that radiographic, physiologic, or biologic measures are able to identify interstitial lung disease at an early stage, are able to define the overall activity of the disease, and are able to predict the course of the lung disorder. During the next five years, the investigators intend to continue to evaluate the clinical utility of these biomarkers for assessing interstitial lung disease. The goal of this project is to identify risk factors that determine the activity of disease and prognosis for patients with interstitial lung disease. Although the applicants and other investigators have found associations between a variety of disease measurements, the clinical utility of biomarkers for assessing interstitial lung disease has not been critically evaluated. While Project I is not designed to study the pathogenesis of interstitial lung disease, knowledge of the pathogenesis of these disorders may suggest now biomarkers for these clinical studies. Moreover, findings from the studies proposed in Project I may enhance and re-direct the pathogenic studies outlined in other projects in this SCOR Program. The investigators will study and compare four types of interstitial lung disease - idiopathic pulmonary fibrosis (IPF), asbestosis, interstitial fibrosis associated with rheumatoid arthritis (RA-ILD), and sarcoidosis. Three of these disorders (IPF, asbestosis, and RA-ILD), have a similar radiographic and histologic appearance. In contrast, sarcoidosis exhibits markedly different radiographic and histologic findings. While all of these disorders involve the interstitium of the lung, the anatomic distribution for these diseases, as detected by the high resolution computerized tomography (HRCT) scan, is decidedly different - sarcoidosis primarily involves the airways and peribronchial parenchyma while the other three lung diseases predominantly involve the lung parenchyma. However, in all of these disorders, the high resolution CT (HRCT) scan is able to identify heterogeneous areas of lung involvement. The etiologic factors and prognosis associated with these four diseases are also clearly different. These differences and similarities will allow the evaluation of risk factors and prognosticators both within and across disease categories. The specific aims have been developed to further pursue and extend the ongoing research program in interstitial lung disease at the University of Iowa.