Structure guided mapping of protein interactions and their perturbation

蛋白质相互作用及其扰动的结构引导绘图

• 批准号: DE200101323
• 负责人: Prof David Ascher
• 金额: --
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2020-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE200101323
• 关键词: Structure; guided; mapping; protein; interactions

Protein interactions are central to most biological processes, and significant effort has been devoted to trying to unravel these complicated networks. This project aims to develop new approaches to better understand these interactions, and the consequences of their perturbation. The main expected contributions will be: (i) methods to identify likely protein interaction sites using population conservation; (ii) computational approaches to assess the effects of any type of mutation on the interaction; and (iii) an understanding of how disruption of a specific interaction can affect the complicated biological network within a cell.

蛋白质相互作用是大多数生物过程的核心，并且已经投入了大量的努力来试图解开这些复杂的网络。该项目旨在开发新的方法来更好地理解这些相互作用及其扰动的后果。主要的预期贡献将是：（一）方法，以确定可能的蛋白质相互作用的网站使用人口保护;（二）计算方法，以评估任何类型的突变的影响的相互作用;和（三）一个特定的相互作用的破坏如何影响细胞内的复杂的生物网络的理解。