High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin Supplement

摘要 神经科学对大规模成像和微扰工具有一个基本要求。 这样的工具将在脑功能图谱和诊断和 神经疾病的治疗。拟议的项目旨在揭示 全脑淋巴和血管血流在阿尔茨海默病进展中的作用 使用新的全脑成像模式的细胞分辨率标尺。我们项目的目标是使用 最先进的活体成像技术研究脑脊液(CSF)在大脑中的流动，以及 在转基因模型中，这种流动如何与AD相关的蛋白质积累相互作用。我们会研究 AD系统中的流程是如何受到干扰的，重点是废品的清除

ABSTRACT Neuroscience has an essential requirement for large-scale imaging and perturbation tools. Such tools would be transformative in the mapping of brain function and the diagnosis and treatment of neurological disorders. The proposed project is aimed at uncovering regulation of glymphatic and vascular flow in the progression of Alzheimer’s disease (AD) at whole-brain, cellular-resolution scales using novel whole-brain imaging modalities. Our project’s goal is to use state-of-the-art in vivo imaging techniques to study cerebrospinal fluid (CSF) flow in the brain, and how this flow interacts with AD-related protein accumulation in transgenic models. We will study how flow in this system is perturbed in AD, with a focus on clearance of waste products