High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin Supplement

摘要 神经科学对大规模成像和扰动工具有着基本的要求。 这些工具将在绘制大脑功能和诊断方面具有变革性， 神经系统疾病的治疗。拟议项目旨在揭示 阿尔茨海默病（AD）全脑进展中的胶质淋巴和血管流动， 细胞分辨率尺度使用新的全脑成像模式。我们项目的目标是利用 研究脑内脑脊液（CSF）流动的最新体内成像技术，以及 这种流动如何与转基因模型中AD相关蛋白质积累相互作用。我们将研究 在AD中，该系统中的流动如何受到扰动，重点是废物的清除

ABSTRACT Neuroscience has an essential requirement for large-scale imaging and perturbation tools. Such tools would be transformative in the mapping of brain function and the diagnosis and treatment of neurological disorders. The proposed project is aimed at uncovering regulation of glymphatic and vascular flow in the progression of Alzheimer’s disease (AD) at whole-brain, cellular-resolution scales using novel whole-brain imaging modalities. Our project’s goal is to use state-of-the-art in vivo imaging techniques to study cerebrospinal fluid (CSF) flow in the brain, and how this flow interacts with AD-related protein accumulation in transgenic models. We will study how flow in this system is perturbed in AD, with a focus on clearance of waste products