课题基金 / 基金详情

High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin Supplement

High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin Supplement
用于行为动物图像引导神经调节的高分辨率双向光声介观神经接口 - RF1 管理补充
批准号:
10712937
负责人:
Robert E. Campbell
金额:
$42.38万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-04-01 至 2025-05-31

项目摘要

项目成果

Robert E. Campbell的其他基金

相关文献

中文摘要
翻译
摘要 神经科学对大规模成像和微扰工具有一个基本要求。 这样的工具将在脑功能图谱和诊断和 神经疾病的治疗。拟议的项目旨在揭示 全脑淋巴和血管血流在阿尔茨海默病进展中的作用 使用新的全脑成像模式的细胞分辨率标尺。我们项目的目标是使用 最先进的活体成像技术研究脑脊液(CSF)在大脑中的流动,以及 在转基因模型中,这种流动如何与AD相关的蛋白质积累相互作用。我们会研究 AD系统中的流程是如何受到干扰的,重点是废品的清除
英文摘要
ABSTRACT Neuroscience has an essential requirement for large-scale imaging and perturbation tools. Such tools would be transformative in the mapping of brain function and the diagnosis and treatment of neurological disorders. The proposed project is aimed at uncovering regulation of glymphatic and vascular flow in the progression of Alzheimer’s disease (AD) at whole-brain, cellular-resolution scales using novel whole-brain imaging modalities. Our project’s goal is to use state-of-the-art in vivo imaging techniques to study cerebrospinal fluid (CSF) flow in the brain, and how this flow interacts with AD-related protein accumulation in transgenic models. We will study how flow in this system is perturbed in AD, with a focus on clearance of waste products
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1038/s41467-023-39069-1
发表时间: 2023-06-16
期刊: NATURE COMMUNICATIONS
影响因子: 16.6
作者: [Dean-Ben, Xose Luis, Robin, Justine, Nozdriukhin, Daniil, Ni, Ruiqing, Zhao, Jim, Gluck, Chaim, Droux, Jeanne, Sendon-Lago, Juan, Chen, Zhenyue, Zhou, Quanyu, Weber, Bruno, Wegener, Susanne, Vidal, Anxo, Arand, Michael, El Amki, Mohamad, Razansky, Daniel]
通讯作者: Razansky, Daniel
High-resolution bidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animals
Optimization of CaMPARI for large-scale, cellular-resolution activity recording in freely-moving mice
  • 批准号:
    10293936
  • 项目类别:
  • 资助金额:
    $61.91万
  • 财政年份:
    2021
  • 负责人:
    Robert E. Campbell
  • 依托单位:
Optimization of CaMPARI for large-scale, cellular-resolution activity recording in freely-moving mice
  • 批准号:
    10472700
  • 项目类别:
  • 资助金额:
    $64.81万
  • 财政年份:
    2021
  • 负责人:
    Robert E. Campbell
  • 依托单位:
Northern Lights collaboration for better 2-photon probes