Lipopolysaccharide-induced macrophage extracellular traps in host defence

脂多糖诱导的巨噬细胞胞外陷阱在宿主防御中的作用

• 批准号: DE200101300
• 负责人: Dr Maria Monteleone
• 金额: $ 29.75万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-13 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE200101300
• 关键词: Lipopolysaccharide; induced; macrophage; extracellular; traps

The innate immune system is the first line of defence against invading microbes. Macrophages are key innate immune cells that deploy antimicrobial responses to clear infection and restore health. There are many critical unanswered questions on the molecular mechanisms that drive macrophage inflammatory and antimicrobial pathways. This project aims to elucidate a novel inflammatory mechanism that immobilises and kills invading bacteria via newly discovered structures made by dying macrophages called extracellular traps. Insight we gain by interrogating this immune cell signalling pathway, called the non-canonical inflammasome, will add valuable knowledge to our fundamental understanding of mammalian inflammation and anti-microbial responses

先天免疫系统是抵御微生物入侵的第一道防线。巨噬细胞是关键的先天性免疫细胞，可以部署抗菌反应以清除感染并恢复健康。关于驱动巨噬细胞炎症和抗菌途径的分子机制，还有许多关键的未解问题。该项目旨在阐明一种新的炎症机制，该机制通过新发现的由垂死的巨噬细胞制成的称为细胞外陷阱的结构来固定和杀死入侵的细菌。我们通过询问这种称为非典型炎性体的免疫细胞信号传导途径获得的见解将为我们对哺乳动物炎症和抗微生物反应的基本理解增加有价值的知识