ANTIHYPERTENSIVE AGENTS FROM RANUNCULACEAE

对药物有效性的当前认识 乌头属、飞燕草属和包头科植物 (毛滴科)是不完整的，需要进一步的调查。 这些属的50多种植物的提取物被用于 它们的镇痛、抗风湿和强心作用 以及印度的医疗体系。 本研究的目标是：(1)分离纯化 要测试的生物碱。(2)活性生物碱的结构修饰 用于增强降压活性。(3)研究机制。 反射接收动作。(4)研究生物碱对人体健康的影响。 自主反射。 将进行足够数量的关键生物碱的分离，以便 可以对这些化合物进行药理学研究。这个 提纯的天然生物碱及其衍生物将被 对CVS活动进行了筛选。前景看好的生物碱 将对降压活性进行结构性修改，以增强最大 治疗效果好，毒性小。

Current understanding of the effectiveness of the drugs derived from plants belonging to Aconitum, Delphinium and Consolida species (Ranunculaceae) is incomplete and further investigations are desirable. Extracts of more than 50 species of plants of these genera are used for their analgesic, antirheumatic and cardiotonic properties in the Chinese and Indian systems of medicine. The objectives of this research proposal are: (1) To isolate and purify the alkaloids to be tested. (2) to modify structures of active alkaloids for enhancement of antihypertensive activity. (3) to study the mechanism of reflex reception action. (4) to study the actions of alkaloids on autonomic reflexes. Isolation of key alkaloids in adequate amounts will be undertaken so that a pharmacological investigation of these compounds can be pursued. The purified naturally-occurring alkaloids and their derivatives will be screened for CVS activities. Alkaloids that manifest promising hypotensive activity will be structurally modified to enhance maximal therapeutic effects and minimal toxicity.