ANTIHYPERTENSIVE AGENTS FROM RANUNCULACEAE

目前对药物有效性的理解来自 属于翠鸟属、翠雀属和Consolida属物种的植物 （毛茛科）是不完整的，进一步的调查是可取的。 这些属的50多种植物的提取物用于 它们在中国的镇痛、抗风湿和强心作用 和印度的医学体系。 本研究的目的是：（1）分离纯化 待测生物碱。 (2)改变活性生物碱的结构 用于增强抗高血压活性。 (3)可能机制 反射接收动作。 (4)研究生物碱的作用 自主神经反射 将进行适量的关键生物碱分离， 可以对这些化合物进行药理学研究。 的 纯化的天然存在的生物碱及其衍生物将 筛选CVS活动。 生物碱表现出有希望的 将在结构上修饰抑制活性以增强最大抑制活性。 治疗效果和最小的毒性。

Current understanding of the effectiveness of the drugs derived from plants belonging to Aconitum, Delphinium and Consolida species (Ranunculaceae) is incomplete and further investigations are desirable. Extracts of more than 50 species of plants of these genera are used for their analgesic, antirheumatic and cardiotonic properties in the Chinese and Indian systems of medicine. The objectives of this research proposal are: (1) To isolate and purify the alkaloids to be tested. (2) to modify structures of active alkaloids for enhancement of antihypertensive activity. (3) to study the mechanism of reflex reception action. (4) to study the actions of alkaloids on autonomic reflexes. Isolation of key alkaloids in adequate amounts will be undertaken so that a pharmacological investigation of these compounds can be pursued. The purified naturally-occurring alkaloids and their derivatives will be screened for CVS activities. Alkaloids that manifest promising hypotensive activity will be structurally modified to enhance maximal therapeutic effects and minimal toxicity.