DNA Replication Stress: Characterizing ground zero for genomic instability

DNA 复制压力：表征基因组不稳定的归零点

• 批准号: DE200100584
• 负责人: Dr Donna Whelan
• 金额: $ 29.81万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-20 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE200100584
• 关键词: DNA; Replication; Stress; Characterizing; ground

The overarching goal of this research is to gain insights into key underlying molecular causes of, and responses to, DNA replication stress - one of the most fundamental biological processes enabling life as we know it. I will use advanced interdisciplinary imaging techniques to directly visualize DNA replication stress structures within cells in order to better understand how cells stop this stress from progressing into DNA damage. Insights into these processes will have the potential to improve preventative and therapeutic approaches to diseases such as cancer and neurodegeneration.

本研究的总体目标是深入了解DNA复制应激的关键潜在分子原因和反应-我们所知的生命最基本的生物学过程之一。我将使用先进的跨学科成像技术直接可视化细胞内的DNA复制应激结构，以便更好地了解细胞如何阻止这种应激进展为DNA损伤。对这些过程的深入了解将有可能改善癌症和神经变性等疾病的预防和治疗方法。