BRAIN STIMULATION MODELS OF DRUG ABUSE

这是一个研究科学家奖（RSA K 05）的请求。 我的未来 研究的主要任务是研究滥用的物质， 同时也为药理学、心理学、 以及行为神经科学研究生和博士后。 的 建议的研究是针对进一步了解我们的 滥用物质奖赏效应的神经基础 强调精神兴奋剂和滥用阿片类药物。 因为 以前的研究结果表明，嗅结节可能发挥作用， 在这两类滥用物质的奖励效应中，我们将 集中我们的一些研究在阐明这个大脑部位， 药物奖励机制 还将包括补充实验 阿片类药物的镇痛作用以及非阿片类药物 药理学变量可能有助于其镇痛作用。 因为我们发现吗啡诱导的大鼠口腔刻板症 可以通过相对低剂量的吗啡重新表达， 在最初的吗啡治疗中，我们进行了一系列的实验， 以确定这些长期影响的机制。这些 实验可能与阿片类药物滥用以及可能的 内源性阿片系统在多动性运动障碍中的作用。 受虐者奖励效应研究中的程序 物质包括肠胃外以及脑内给药 受体特异性激动剂和拮抗剂。我们使用的主要方法 研究这些药理学操作的影响是脑- 刺激奖励、药物自我给药和定量2-[14 C] 脱氧葡萄糖法测定局部脑葡萄糖利用率。

This is a request for a Research Scientist Award (RSA K05). My future research will have as its major commitment the study of abused substances as well as provide a laboratory for training of pharmacology, psychology and behavioral neuroscience graduate and postdoctoral students. The proposed research is directed toward furthering our understanding of the neuronal bases of the rewarding effects of abused substances with special emphasis on the psychomotor stimulants and the abused opioids. Because of previous findings suggesting that the olfactory tubercle may play a role in the rewarding effects of these two classes of abused substances we will focus some of our research on the elucidation of this brain site in the mechanism of drug reward. Also included will be complementary experiments of the analgesic effects of opiate drugs and the manner that non- pharmacological variables may contribute to their analgesic effects. Because of our finding that morphine-induced oral stereotypy in the rat can be re-expressed by a comparatively low dose of morphine months after the initial morphine treatment we have embarked on a series of experiments to determine the mechanisms involved in these long term effects. These experiments may have relevance for both opioid abuse as well as a possible role of the endogenous opioid system in hyperkinetic movement disorders. The procedures used in the study of the rewarding effects of abused substances involve the parenteral as well as intracerebral administration of receptor specific agonist and antagonist. The major methods we use to study the effects of these pharmacological manipulations are brain- stimulation reward, drug self-administration and the quantitative 2-[14C) deoxyglucose method of determining local cerebral glucose utilization.