BRAIN STIMULATION MODELS OF DRUG ABUSE

药物滥用的大脑刺激模型

• 批准号: 2115909
• 负责人: CONAN KORNETSKY
• 金额: $ 10.38万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-12-10 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2115909
• 关键词: 6 hydroxydopamine; central nervous system stimulants; chordate locomotion; cocaine; dopamine; drug abuse; laboratory rat; morphine; naloxone; nucleus accumbens; olfactory lobe; opiate alkaloid; oral behavior; psychological reinforcement; psychopharmacology; reinforcer; self medication; videotape /videodisc

This is a request for a Research Scientist Award (RSA K05). My future research will have as its major commitment the study of abused substances as well as provide a laboratory for training of pharmacology, psychology and behavioral neuroscience graduate and postdoctoral students. The proposed research is directed toward furthering our understanding of the neuronal bases of the rewarding effects of abused substances with special emphasis on the psychomotor stimulants and the abused opioids. Because of previous findings suggesting that the olfactory tubercle may play a role in the rewarding effects of these two classes of abused substances we will focus some of our research on the elucidation of this brain site in the mechanism of drug reward. Also included will be complementary experiments of the analgesic effects of opiate drugs and the manner that non- pharmacological variables may contribute to their analgesic effects. Because of our finding that morphine-induced oral stereotypy in the rat can be re-expressed by a comparatively low dose of morphine months after the initial morphine treatment we have embarked on a series of experiments to determine the mechanisms involved in these long term effects. These experiments may have relevance for both opioid abuse as well as a possible role of the endogenous opioid system in hyperkinetic movement disorders. The procedures used in the study of the rewarding effects of abused substances involve the parenteral as well as intracerebral administration of receptor specific agonist and antagonist. The major methods we use to study the effects of these pharmacological manipulations are brain- stimulation reward, drug self-administration and the quantitative 2-[14C) deoxyglucose method of determining local cerebral glucose utilization.

这是获得研究科学家奖（RSA K05）的要求。 我的未来 研究将作为对滥用物质的研究的主要承诺 以及为培训药理学，心理学提供实验室 以及行为神经科学的毕业生和博士后生。 这 拟议的研究旨在促进我们对 特殊的滥用物质的奖励作用的神经元基础 强调精神运动兴奋剂和虐待的阿片类药物。 由于 以前的发现表明嗅觉结节可能起作用 在这两类滥用物质的奖励效果中，我们将 将我们的一些研究集中在阐明该大脑部位 药物奖励的机制。 还包括补充实验 阿片类药物的镇痛作用以及非 药理变量可能会导致其镇痛作用。 因为我们发现吗啡诱导的大鼠口服刻板印象 可以通过几个月后的吗啡来重新表达 我们开始进行一系列实验的最初吗啡治疗 确定这些长期影响所涉及的机制。这些 实验可能与阿片类药物滥用以及可能 内源性阿片类系统在超动运动障碍中的作用。 研究滥用的奖励效果的过程 物质涉及肠胃外和脑内给药 受体特异性激动剂和拮抗剂。我们使用的主要方法 研究这些药理操作的效果是大脑 刺激奖励，药物自我给药和定量2- [14C） 脱氧葡萄糖确定局部脑葡萄糖利用的方法。