课题基金 / 基金详情

MUCOSAL AND SYSTEMIC IMMUNITY TO SIV AND HIV ANTIGENS

MUCOSAL AND SYSTEMIC IMMUNITY TO SIV AND HIV ANTIGENS
对 SIV 和 HIV 抗原的粘膜和系统免疫
批准号:
3747022
负责人:
PRESTON A MARX
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:

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中文摘要
翻译
这项研究的总体目标是开发出能够保护人类的疫苗
英文摘要
The overall goal of this study is to develop vaccines that will protect male and female macaques from genital SIV transmission. Protection studies in macaques against intravenous challenges with SIV have been successful, but HIV vaccines for humans must also protect against a heterosexual route of infection. In our previous NCVDG studies, female macaques were protected against vaginal challenges. Protection was achieved when animals were immunized with formalin-treated SIV in biodegradable microspheres only if primed intramuscularly and boosted by oral (OR) or intratracheal (IT) routes. OR immunization alone did not protect. The data suggest that microspheres may serve as a basic vaccine strategy for protection against HIV vaginal transmission. This renewal application develops microsphere-based vaccines and other strategies for protection against heterosexual transmission, using the following specific aims: Aim 1. To identify the best of three immunization strategies for induction of vaginal antibody and to determine which strategy is best for protection against vaginal SIV challenge. The three strategies are intramuscular (IM) immunization only, IM priming plus OR boosting and IM priming plus IT boosting. Aim 2. To test recombinant SIV formulations consisting of SIV expressed proteins in microspheres for induction of vaginal IgG and IgA levels that are comparable to our previous results with whole SIV-microsphere immunizations. We will also determine if these SIV-recombinant- microsphere immunized animals are protected against vaginal challenge. Aim 3. To produce concentrated vaginal SIV antibody for testing its functions in neutralization and other immunological assays. Aim 4. To compare the thigh and arm muscles as intramuscular immunization sites for priming the induction of SIV vaginal immunity. Aim 5. To conduct immunogenicity studies in macaques using HIV recombinant antigens for inducing vaginal and systemic immunity. Aim 6. To develop a reliable male genital SIV challenge system.
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会议论文
HETEROSEXUAL TRANSMISSION OF AIDS--A SIMIAN MODEL
PATHOGENESIS OF SIV IN ASIAN AND AFRICAN MONKEY
SIMIAN RETROVIRUSES IN HUMAN AND NON-HUMAN PRIMATES
SIMIAN RETROVIRUSES IN HUMAN AND NON-HUMAN PRIMATES
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