Mucosal immunity to human immunodeficiency virus

对人类免疫缺陷病毒的粘膜免疫

• 批准号: nhmrc : 1026293
• 负责人: Prof Andreas Suhrbier
• 金额: $ 39.07万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mucosal-immunity-human-immunodeficiency-virus/110484
• 关键词: Mucosal; immunity; human; immunodeficiency; virus

We will construct different genetically engineered viruses, which infect cells in the respiratory tract, to deliver genes encoding proteins from human immunodeficiency virus (the AIDS virus). These engineered viruses can be expected to generate an active immune response in mucosal tissues, including the vaginal and rectal tracts. As these are the major routes for transmission of the AIDS virus, these new vaccines are expected to reduce transmission of the AIDS virus.

我们将构建不同的基因工程病毒，感染呼吸道细胞，传递编码人类免疫缺陷病毒（艾滋病病毒）蛋白质的基因。这些工程病毒可在粘膜组织（包括阴道和直肠束）中产生积极的免疫反应。由于这些是艾滋病病毒传播的主要途径，预计这些新疫苗将减少艾滋病病毒的传播。