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SOFTWARE TO COMPENSATE FOR INTERRUPTIONS IN RADIOTHERAPY

SOFTWARE TO COMPENSATE FOR INTERRUPTIONS IN RADIOTHERAPY
补偿放射治疗中断的软件
批准号:
2106038
负责人:
RAINER K SACHS
金额:
$7.5万
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-06-01 至 1994-11-30

项目摘要

项目成果

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中文摘要
翻译
通常,癌症放射治疗持续一个月以上,而且 大约一半的患者会出现计划外的治疗中断。 肿瘤和周围正常组织受到不同程度的影响 由于生长速度和细胞修复的差异而造成的中断 能力。因此,对中断进行最佳补偿 需要基于细胞放射生物学的估计。目前已接受 将使用最先进的放射生物学技术作为基础 为个人计算机设计和编写易于使用的软件 或Macintosh,这使放射肿瘤学家可以获得 针对计划外中断的各种补偿选项。这个 软件还将指出每个选项可能存在的缺陷。这个 项目将足够简单,每个项目至少有一名专业人员 放射肿瘤学设施将能够互动地使用它们, 彻底了解它们的含义。关于中国农业科技发展的初步研究 将放射生物学概念整合为全尺度的可行性 治疗计划的计算机代码也将被执行。
英文摘要
Typically, cancer radiation therapy lasts more than a month, and unplanned treatment interruptions occur for about half of all patients. Tumors and surrounding normal tissues are affected differently by such interruptions, due to differences in growth rates and in cellular repair capabilities. Consequently, optimally compensating for interruptions requires estimates based on cellular radiobiology. Currently accepted state-of-the-art techniques in radiobiology will be used as a basis for designing and writing readily usable software, for a personal computer or a Macintosh, which makes available to the radiation oncologist a variety of compensation options for unplanned interruptions. The software will also indicate possible drawbacks of each option. The programs will be simple enough that at least one professional at each radiation oncology facility will be able to use them interactively, with a thorough understanding of their implications. Preliminary studies on the feasibility of integrating radiobiological concepts into full-scale treatment-planning computer codes will also be carried out.
期刊论文(16)
专著(0)
科研奖励(0)
会议论文
DOI: 10.2307/3579648
发表时间: 1998-07-01
期刊: RADIATION RESEARCH
影响因子: 3.4
作者: [Brenner, DJ, Hlatky, LR, Sachs, RK]
通讯作者: Sachs, RK
Pulsed dose-rate brachytherapy.
脉冲剂量率近距离放射治疗。
DOI: 10.1016/s0167-8140(97)00166-7
发表时间: 1997
期刊: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
影响因子: --
作者: [Hall,EJ, Brenner,DJ]
通讯作者: Brenner,DJ
Recent data obtained by pulsed-field gel electrophoresis suggest two types of double-strand breaks.
最近通过脉冲场凝胶电泳获得的数据表明存在两种类型的双链断裂。
DOI: --
发表时间: 1998
期刊: Radiation research.
影响因子: --
作者: [Radivoyevitch,T, Hoel,DG, Hahnfeldt,PJ, Rydberg,B, Sachs,RK]
通讯作者: Sachs,RK
Intra-arm and interarm chromosome intrachanges: tools for probing the geometry and dynamics of chromatin.
臂内和臂间染色体内部变化:探测染色质几何形状和动力学的工具。
DOI: --
发表时间: 1997
期刊: Radiation research.
影响因子: --
作者: [Sachs,RK, Brenner,DJ, Chen,AM, Hahnfeldt,P, Hlatky,LR]
通讯作者: Hlatky,LR
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