INTERACTION OF CARDIOVASCULAR REFLEXES IN THERMAL STRAIN
热应变中心血管反射的相互作用
基本信息
- 批准号:2219380
- 负责人:
- 金额:$ 22.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-09-30 至 1999-07-31
- 项目状态:已结题
- 来源:
- 关键词:aerobic exercise antiadrenergic agents baroreceptors baroreflex blood circulation body temperature regulation body water dehydration cardiovascular function carotid artery electrocardiography flame photometry heat heterodyning human subject oral pharyngeal physical fitness physiologic stressor radioimmunoassay skin circulation sweat sympathetic nervous system syncope vasoconstriction water drinking behavior
项目摘要
It is well documented that aerobic exercise training provides an
individual with a pronounced thermoregulatory and circulatory advantage
during exercise in the heat. The ability to prevent excessive
hyperthermia during conditions of high thermal and circulatory strain is
dependent on a complex interaction between reflexes that regulate heat
dissipating mechanisms and non-thermoregulatory (circulatory) reflexes.
The long-term objectives of this project are to describe the
physiological mechanisms involved in the interaction between control
systems which regulated arterial blood pressure and those which regulate
body temperature. We are particularly interested in baroreflex control
of cutaneous vasoconstrictor activity and how it is influenced by thermal
status and/or physical fitness. Our specific aims of over the next five
years are: l) to characterize spatial heterogeneities in baroreflex
mediated cutaneous vasoconstriction 2) to demonstrate attenuated
baroreceptor mediated increases in sympathetic vasoconstrictor activity
in hyperthermic humans. 3) to identify the mechanism by which
thermoregulatory responses to thermal stress are attenuated by
baroreceptor unloading. 4) to examine the role of oropharyngeal reflexes
in reversing the inhibitory influence of dehydration on heat loss
mechanisms in thermally stressed humans. To accomplish these goals we
will create topographical perfusion maps of relatively large areas of the
skin microvasculature with the aid of a computer-guided stereotaxic laser
Doppler velocimetry system, monitor sympathetic vasoconstrictor nerve
activity directly via microneurographic techniques, and modify local
sympathetic adrenergic responses in the skin with selective adrenergic
blocking agents. We will relate the circulatory and thermoregulatory
responses (i.e. changes in sympathetic nerve activity, skin blood flow,
or sweating) to their primary physiological stimuli (i.e. changes in
central venous or carotid artery pressure or body core temperature). We
expect to demonstrate that baroreflex control of circulatory function is
altered by the thermal status of the individual and is dependent, in
part, on their level of aerobic fitness. In addition, we expect to
demonstrate that the interaction between baroreceptor and
thermoregulatory control of skin blood flow occurs at a site more
proximal than the cutaneous arterioles. Thermal status will be
manipulated using passive heating and/or exercise while baroreceptor
mediated increases in sympathetic nerve activity will be accomplished by
application of lower body negative pressure and/or carotid neck pressure.
These studies should improve our understanding of the control of arterial
blood pressure during conditions of thermal stress and provide new
knowledge about the mechanisms that humans employ to resist syncope in
conditions of high circulation and thermal stress.
有充分的证据表明,有氧运动训练提供了一个
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GARY W MACK其他文献
GARY W MACK的其他文献
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{{ truncateString('GARY W MACK', 18)}}的其他基金
INTERACTION OF CARDIOVASCULAR REFLEXES IN THERMAL STRAIN
热应变中心血管反射的相互作用
- 批准号:
2750330 - 财政年份:1988
- 资助金额:
$ 22.37万 - 项目类别:
INTERACTION OF CARDIOVASCULAR REFLEXES IN THERMAL STRAIN
热应变中心血管反射的相互作用
- 批准号:
6640886 - 财政年份:1988
- 资助金额:
$ 22.37万 - 项目类别:
INTERACTION OF CARDIOVASCULAR REFLEXES IN THERMAL STRAIN
热应变中心血管反射的相互作用
- 批准号:
2219381 - 财政年份:1988
- 资助金额:
$ 22.37万 - 项目类别:
INTERACTION OF CARDIOVASCULAR REFLEXES IN EXERCISE
运动中心血管反射的相互作用
- 批准号:
3471793 - 财政年份:1988
- 资助金额:
$ 22.37万 - 项目类别:
INTERACTION OF CARDIOVASCULAR REFLEXES IN THERMAL STRAIN
热应变中心血管反射的相互作用
- 批准号:
6127058 - 财政年份:1988
- 资助金额:
$ 22.37万 - 项目类别:
INTERACTION OF CARDIOVASCULAR REFLEXES IN EXERCISE
运动中心血管反射的相互作用
- 批准号:
3471794 - 财政年份:1988
- 资助金额:
$ 22.37万 - 项目类别:
INTERACTION OF CARDIOVASCULAR REFLEXES IN THERMAL STRAIN
热应变中心血管反射的相互作用
- 批准号:
2459949 - 财政年份:1988
- 资助金额:
$ 22.37万 - 项目类别:
INTERACTION OF CARDIOVASCULAR REFLEXES IN EXERCISE
运动中心血管反射的相互作用
- 批准号:
3471792 - 财政年份:1988
- 资助金额:
$ 22.37万 - 项目类别:
INTERACTION OF CARDIOVASCULAR REFLEXES IN EXERCISE
运动中心血管反射的相互作用
- 批准号:
3471791 - 财政年份:1988
- 资助金额:
$ 22.37万 - 项目类别:
INTERACTION OF CARDIOVASCULAR REFLEXES IN EXERCISE
运动中心血管反射的相互作用
- 批准号:
3471789 - 财政年份:1988
- 资助金额:
$ 22.37万 - 项目类别: