Mastering pyrimidine editing in RNA

掌握 RNA 中的嘧啶编辑

• 批准号: DP200102981
• 负责人: Prof Ian Small
• 金额: $ 42.86万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102981
• 关键词: Mastering; pyrimidine; editing; RNA

Many plants and animals can alter their genetic information via RNA (ribonucleic acid) editing, a process that is often essential for the growth and development of the organism. This ability provides accurate control over gene expression and has great potential as a biotechnological tool in agriculture and medicine. RNA editing could be used to switch genes on or off in biotechnological production systems with an unprecedented degree of precision, or to correct genetic diseases. This project aims to understand two RNA editing pathways in plants, one of which is found nowhere else and likely to involve a novel enzymatic mechanism. We will use the understanding gained to develop novel RNA processing tools usable in any living organism.

许多动植物可以通过RNA（核糖核酸）编辑来改变其遗传信息，这一过程通常对于生物的生长和发育至关重要。这种能力提供了对基因表达的准确控制，并且具有巨大的潜力作为农业和医学中的生物技术工具。 RNA编辑可用于在具有前所未有的精度或纠正遗传疾病的生物技术生产系统中打开或关闭基因。该项目旨在了解植物中的两种RNA编辑途径，其中一个无处可寻，可能涉及一种新型的酶促机制。我们将利用获得的理解来开发新型的RNA处理工具，可在任何生物体中使用。