Mastering pyrimidine editing in RNA

掌握 RNA 中的嘧啶编辑

• 批准号: DP200102981
• 负责人: Prof Ian Small
• 金额: $ 42.86万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102981
• 关键词: Mastering; pyrimidine; editing; RNA

Many plants and animals can alter their genetic information via RNA (ribonucleic acid) editing, a process that is often essential for the growth and development of the organism. This ability provides accurate control over gene expression and has great potential as a biotechnological tool in agriculture and medicine. RNA editing could be used to switch genes on or off in biotechnological production systems with an unprecedented degree of precision, or to correct genetic diseases. This project aims to understand two RNA editing pathways in plants, one of which is found nowhere else and likely to involve a novel enzymatic mechanism. We will use the understanding gained to develop novel RNA processing tools usable in any living organism.

许多植物和动物可以通过RNA(核糖核酸)编辑来改变它们的遗传信息，这一过程通常对生物体的生长和发育至关重要。这种能力提供了对基因表达的精确控制，并具有作为农业和医学生物技术工具的巨大潜力。RNA编辑可以用来在生物技术生产系统中以前所未有的精度打开或关闭基因，或者用于纠正遗传病。该项目旨在了解植物中的两条RNA编辑途径，其中一条在其他地方没有发现，可能涉及一种新的酶机制。我们将利用所获得的理解来开发可用于任何活着的有机体的新型RNA处理工具。