Controlling gene expression with synthetic RNA-binding proteins

用合成 RNA 结合蛋白控制基因表达

• 批准号: FL140100179
• 负责人: Prof Ian Small
• 金额: $ 194.69万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-12-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL140100179
• 关键词: Controlling; gene; expression; synthetic; RNA

Controlling gene expression with synthetic RNA-binding proteins. The growth and development of living organisms is largely determined by the genes they contain, but converting the genetic information into biological activity requires intermediary processes involving RNA and proteins that bind to and process RNA. This project aims to understand how the largest class of RNA-binding protein in plants recognise their target RNAs and aims to develop custom-designed proteins for switching genes on or off. This technology will be used to create new hybrid cereal varieties and will also be valuable for applications in human health, such as the correction of genetic mutations.

用合成的RNA结合蛋白控制基因表达。生物体的生长和发育在很大程度上取决于它们所含的基因，但将遗传信息转化为生物活性需要涉及RNA和与RNA结合并加工RNA的蛋白质的中间过程。该项目旨在了解植物中最大的一类RNA结合蛋白如何识别其靶RNA，并旨在开发定制设计的蛋白质以打开或关闭基因。这项技术将用于创造新的杂交谷物品种，也将对人类健康的应用有价值，如纠正基因突变。