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SELECTIVE LASER ATHERECTOMY--THE ROLE OF CAROTENOIDS

选择性激光动脉粥样硬化斑块切除术——类胡萝卜素的作用

基本信息

批准号：
2222880
负责人：
MARTIN R PRINCE
金额：
$ 16.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
起止时间：
1992-02-01 至 1995-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2222880
关键词：
atherosclerotic plaque carotene carotenoids chemical structure coronary artery coronary occlusion /thrombosis disease /disorder model endarterectomy fiber optics laboratory rabbit laser therapy

项目摘要

Although lasers can effectively ablate atherosclerotic plaque, their clinical application is limited by difficulties in confining the effects of laser radiation to the plaque. Inadvertent irradiation of adjacent or underlying normal artery frequently causes perforations, dissections, spasm, pain and thrombosis. The goal of this proposal is to enhance the specificity of laser radiation for plaque by the use of naturally occurring chromophores: carotenoids. These compounds accumulate in plaque but not in normal artery and enhance selectivity by increasing the absorption of laser light by plaque in a spectral region where there is minimal absorption by normal artery. The optimal carotenoids for enhancing selectivity will be determined by first identifying the carotenoids that naturally accumulate in human plaque, and then determining which of these confers the greatest preferential absorption in the shortest period of time in an animal model of atherosclerosis. Characterizing the carotenoids found in human plaque will identify molecular structural features and physical-chemical properties which confer affinity for plaque. This may also help to explain the recently discovered association of beta carotene, a common carotenoid, with a significant reduction in myocardial infarction, stroke and vascular surgery. Once the optimal carotenoids are identified, their potential for enhancing the quality and selectivity of laser atherectomy will be assessed in an atherosclerotic animal model. Identifying those human plaques which accumulate the greatest amount of carotenoids will determine which types of atherosclerotic plaque have the greatest preferential absorption and thus, are best suited for removal by selective laser atherectomy. This research not only explores fundamental aspects of the interaction of carotenoids with atherosclerotic plaque but is successful, may result in a safer, more effective method for removing atherosclerotic arterial obstructions.

虽然激光可以有效地消融动脉粥样硬化斑块，由于难以限制药物的作用，临床应用受到限制激光辐射到斑块。意外照射邻近或下面的正常动脉经常引起穿孔，夹层，痉挛疼痛和血栓形成该提案的目的是加强通过使用天然存在的发色团：类胡萝卜素。这些化合物在牙菌斑中积累，在正常动脉和增强选择性，通过增加吸收在光谱区域中，正常动脉吸收。最佳类胡萝卜素增强选择性将通过首先鉴定类胡萝卜素来确定，自然地积累在人体斑块中，然后确定哪些这些在最短的时间内提供最大的优先吸收动脉粥样硬化动物模型中。表征类胡萝卜素将识别分子结构特征，赋予牙菌斑亲和力的物理化学性质。这可能也有助于解释最近发现的β-胡萝卜素，一种常见的类胡萝卜素，可以显著减少心肌梗死，中风和血管手术一旦确定了最佳的类胡萝卜素，它们在提高激光质量和选择性方面的潜力将在动脉粥样硬化动物模型中评估斑块切除术。识别那些积累最多的人类斑块类胡萝卜素将决定哪种类型的动脉粥样硬化斑块具有最大的优先吸收，因此，最适合通过选择性激光斑块切除术这项研究不仅探讨了相互作用的基本方面，类胡萝卜素与动脉粥样硬化斑块，但成功，可能会导致更安全、更有效的动脉粥样硬化切除方法障碍物

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

3D gadolinium-enhanced MR angiography of the carotid arteries.

颈动脉 3D 钆增强 MR 血管造影。

DOI：
10.1016/0730-725x(96)00091-4
发表时间：
1996
期刊：
Magnetic resonance imaging
影响因子：
2.5
作者：
Cloft,HJ;Murphy,KJ;Prince,MR;Brunberg,JA
通讯作者：
Brunberg,JA

Beta carotene uptake into atherosclerotic plaque: enhanced staining and preferential ablation with the pulsed dye laser.

动脉粥样硬化斑块吸收 β 胡萝卜素：使用脉冲染料激光增强染色和优先消融。

DOI：
10.1002/lsm.1900130202
发表时间：
1993
期刊：
Lasers in surgery and medicine
影响因子：
2.4
作者：
Mitchell,DC;Prince,MR;Frisoli,JK;Smith,RE;Wood,RF
通讯作者：
Wood,RF

Gadolinium-enhanced magnetic resonance angiography of abdominal aortic aneurysms.

腹主动脉瘤钆增强磁共振血管造影。

DOI：
10.1016/s0741-5214(95)70197-4
发表时间：
1995
期刊：
Journal of vascular surgery
影响因子：
4.3
作者：
Prince,MR;Narasimham,DL;Stanley,JC;Wakefield,TW;Messina,LM;Zelenock,GB;Jacoby,WT;Marx,MV;Williams,DM;Cho,KJ
通讯作者：
Cho,KJ

Pharmacokinetics of a fluorescent drug using laser-induced fluorescence.

使用激光诱导荧光的荧光药物的药代动力学。