CARDIOVASCULAR CONSEQUENCES OF SLEEP APNEA

睡眠呼吸暂停对心血管的影响

• 批准号: 2232050
• 负责人: JOHN A ROBBINS
• 金额: $ 37.59万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2232050
• 关键词: CARDIOVASCULAR; CONSEQUENCES; SLEEP; APNEA

The aim of this multicenter observational study is to determine the prevalence of and the degree to which sleep apnea is an independent or contributing risk factor for the development of cardiovascular or cerebrovascular disease. This application is for a Clinical Center. It is a joint proposal from Cardiovascular Health Study (CHS) at the University of California Davis and the University of Pittsburgh. The population from which participants will be selected includes 2,80& individuals over the age of 66. African Americans make up 20% of the age and gender stratified cohort. Well defined cardiovascular disease prevalence data has been gathered for more than 5 years on most of the cohort. This will allow the identification true incident events. Approximately 1 ,000 study participants will be recruited from the CHS cohort, allowing for stratification by age, race, and gender. Standardized baseline measures of all major cardiovascular risk factors have been obtained. Objective measures of sleep disorders will be gathered in 3 stages: 1) nocturnal pulse oximetry to detect repetitive oxygen desaturation in all participants, 2) eight channel home monitoring of sleep for all those with positive stage 1 tests, and 3) full polysomnography in a local sleep laboratory for a small subset of those with positive stage 2 results. Participants will be closely followed for at least 5 years for cardiovascular morbidity and mortality by CHS. All baseline and follow-up results will be sent to a Data Coordinating Center for analyses.

这项多中心观察性研究的目的是确定 睡眠呼吸暂停的患病率和程度是一个独立的或 导致心血管疾病发展的风险因素，或 脑血管疾病本申请适用于临床中心。是 一项来自大学心血管健康研究（CHS）的联合提案， 来自加州戴维斯和匹兹堡大学。民众免受 参加者将被选中包括2，80和个人以上， 66岁。非裔美国人占年龄和性别分层的20% 队列。明确定义的心血管疾病患病率数据已经 收集了超过5年的大部分队列。这将允许 识别真实事件。约1000项研究 参与者将从CHS队列中招募， 按年龄、种族和性别分层。 标准化基线措施 所有主要的心血管危险因素。目的 睡眠障碍的测量将分为3个阶段：1）夜间 脉搏血氧仪检测所有患者的重复性氧饱和度下降 参与者，2）8通道家庭睡眠监测所有那些 第1阶段试验阳性，以及3）局部睡眠中的完整多导睡眠图 实验室为那些有积极的阶段2结果的一小部分。 参与者将被密切跟踪至少5年， CHS的心血管发病率和死亡率。 所有基线和随访 结果将被发送到数据协调中心进行分析。