CARDIOVASCULAR CONSEQUENCES OF SLEEP APNEA

睡眠呼吸暂停对心血管的影响

• 批准号: 2771407
• 负责人: JOHN A ROBBINS
• 金额: $ 14.16万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2771407
• 关键词: age difference; cardiovascular disorder; cardiovascular disorder epidemiology; cooperative study; data collection; disease /disorder proneness /risk; gender difference; human subject; oximetry; patient monitoring device; polysomnography; racial /ethnic difference; sleep apnea; sleep disorders

The aim of this multicenter observational study is to determine the prevalence of and the degree to which sleep apnea is an independent or contributing risk factor for the development of cardiovascular or cerebrovascular disease. This application is for a Clinical Center. It is a joint proposal from Cardiovascular Health Study (CHS) at the University of California Davis and the University of Pittsburgh. The population from which participants will be selected includes 2,80& individuals over the age of 66. African Americans make up 20% of the age and gender stratified cohort. Well defined cardiovascular disease prevalence data has been gathered for more than 5 years on most of the cohort. This will allow the identification true incident events. Approximately 1 ,000 study participants will be recruited from the CHS cohort, allowing for stratification by age, race, and gender. Standardized baseline measures of all major cardiovascular risk factors have been obtained. Objective measures of sleep disorders will be gathered in 3 stages: 1) nocturnal pulse oximetry to detect repetitive oxygen desaturation in all participants, 2) eight channel home monitoring of sleep for all those with positive stage 1 tests, and 3) full polysomnography in a local sleep laboratory for a small subset of those with positive stage 2 results. Participants will be closely followed for at least 5 years for cardiovascular morbidity and mortality by CHS. All baseline and follow-up results will be sent to a Data Coordinating Center for analyses.

这项多中心观察性研究的目的是确定 睡眠呼吸暂停的患病率和程度是独立的或 心血管疾病发生的危险因素 脑血管疾病。此应用程序适用于临床中心。它是 来自该大学心血管健康研究(CHS)的联合提案 加州大学戴维斯分校和匹兹堡大学。中国的人口 入选的参赛者包括2，80名个人 现年66岁。非洲裔美国人占年龄和性别分层的20% 一群人。定义明确的心血管疾病流行数据一直是 在大多数队列中聚集了超过5年的时间。这将允许 识别真实的事件事件。大约1,000项研究 参与者将从CHS队列中招募，允许 按年龄、种族和性别分层。标准化基线衡量标准 在所有主要的心血管危险因素中，已获得。客观化 睡眠障碍的衡量标准将分三个阶段收集：1)夜间睡眠 脉搏血氧饱和度测定检测急性淋巴细胞白血病患者反复血氧饱和度 参与者，2)为所有有睡眠障碍的人提供八通道家庭睡眠监测 阶段1试验阳性，以及3)局部睡眠中的全面多导睡眠图 实验室用于阶段2结果呈阳性的一小部分患者。 参与者将被密切跟踪至少5年 CHS的心血管发病率和死亡率。所有基线和后续行动 结果将被发送到数据协调中心进行分析。