ENDOGENOUS ERPS IN OBSESSIVE-COMPULSIVE DISORDER

简介(摘自申请者的摘要)：本项目研究 强迫症患者认知功能障碍的电生理相关性 强迫症(OCD)。事件相关脑异常 强迫症的电位(ERPs)，特别是增强的N200和注意- 相关加工负性(ND)，与假设一致 过度唤醒和过度关注强迫症。调查员提议 进一步评估这一假说并探索区域半球 强迫症患者在听觉任务中测量事件相关电位的差异 不同的认知需求和使用扩展的头皮阵列 电极。事件相关电位的临床与神经学相关性检测 强迫症的异常也将继续评估这一假设 强迫症是一种“异质诊断综合症”。 研究旨在帮助识别具有独特特征的强迫症亚型 病理生理和临床特征，即症状严重程度和 治疗结果。 80例强迫症患者的事件相关电位成分(N200、ND、P300)及行为反应 患者，30名患有其他焦虑症(社交)的患者对照 恐惧症或恐慌症)，并对30名正常对照进行测量 在双耳古怪任务、定向注意任务和二分任务中 听力任务。动词(无意义的音节)和非动词(复合词 语调)版本的每个任务将被用来进一步评估假设 关于强迫症患者左脑过度活动和功能障碍的问题。 静息脑电阿尔法功率也将被测量以提供一个指数 大脑皮层觉醒。所有患者在停药两周后将接受检查。 期间，至少有30名强迫症患者将在12岁后重新接受测试 使用抗强迫症药物(氯丙咪嗪)治疗数周 和/或行为疗法。这将决定ERP是否 强迫症的异常随着临床的改善而正常化。

DESCRIPTION (adapted from applicant's abstract): This project studies electrophysiological correlates of cognitive dysfunction in obsessive- compulsive disorder (OCD). Abnormalities of event-related brain potentials (ERPs) in OCD, in particular enhanced N200 and attention- related processing negativity (Nd), are consistent with a hypothesis of overaroused and overfocused attention to OCD. The investigator proposes to further evaluate this hypothesis and explore regional hemispheric differences in OCD patients by measuring ERPs during auditory tasks with varying cognitive demands and by using an expanded array of scalp electrodes. Examination of clinical and neurological correlates of ERP abnormalities in OCD will also continue to evaluate the hypothesis that OCD is a "heterogeneous diagnostic syndrome."A long range goal of this research is to help identify OCD subtypes with distinctive pathophysiology and clinical features, i.e., symptom severity and outcome of treatment. ERP components (N200, Nd, P300) and behavioral responses of 80 OCD patients, 30 patient controls with other anxiety disorders (social phobia or panic disorders), and 30 normal controls will be measured during binaural oddball tasks, directed attention tasks, and dichotic listening tasks. A verbal (nonsense syllable) and nonverbal (complex tone) version of each task will be used to further evaluate hypotheses concerning left hemisphere overactivation and dysfunction in OCD. Resting EEG alpha power will also be measured to provide an index of cortical arousal. All patients will be tested after a 2 week drug-free period, and a minimum of 30 OCD patients will be retested following 12 weeks of treatment with an antiobsessional medication (clomipramine) and/or behavior therapy. This will determine whether or not ERP abnormalities in OCD are normalized following clinical improvement.