ENDOGENOUS ERPS IN OBSESSIVE-COMPULSIVE DISORDER

先前的研究发现，大脑事件相关的独特变化 强迫症(OCD)的电位(ERP)，例如，降低 N200/P300潜伏期和增强的负性。我们的长期目标是 帮助澄清CNS机制的性质，这些机制在 通过评估强迫症患者和对照组之间的差异 内源性ERP组件，每个组件都被认为反映了 信息处理的特定阶段。被动注意和主动注意 任务将用于确定N200中的特定组件- 强迫症患者的P300波群发生改变。任务旨在 测量注意相关的加工负性(ND)和偶然性 负变异(CNV)将检验有关存在的假设 注意力过度集中以及强迫症的过度怀疑和不确定性。 此外，ERP组件的横向不对称性与 双音节任务的认知不对称性将为 评估左半球过度活动和功能障碍的假说 强迫症患者。拟议的项目还将调查：a)诊断 使用社交恐惧症对照研究强迫症的事件相关电位结果的特异性 组；b)事件相关电位异常与症状类型和 强迫症的严重程度；以及c)强迫症的关键ERP异常是否代表 治疗成功后的稳定(特征)特征或变化 服用抗强迫症药物。 具体来说，40名强迫症患者，20名社交恐惧症对照组和20名正常 将在四个ERP任务上测试控制；被动注意任务，以及 主动注意任务、定向注意任务和选择反应 时间CNV任务以及声韵辨析 任务。强迫症患者和社交恐惧症患者在服用最低限度的药物后进行测试- 14天的自由期，强迫症患者在12周后重新测试 抗强迫症调解的治疗，氟西汀在大多数情况下 案子。正常对照将在相同的测试中重新测试-重新测试 作为强迫症患者的时间间隔。

Prior studies have found distinctive alterations of brain event-related potentials (ERPs) in obsessive-compulsive disorder (OCD), e.g., reduced N200/P300 latency and enhanced negativities. Our long range goal is to help clarify the nature of the CNS mechanisms that may be different in OCD by assessing differences between OCD patients and controls in endogenous ERP components, each of which is thought to reflect a specific stage of information processing. Passive and active attention tasks will be used to identify the specific components within the N200- P300 complex that are altered in OCD patients. Tasks designed to measure attention-related processing negativity (Nd) and the contingent negative variation (CNV) will test hypotheses concerning the existence of overfocused attention and excessive doubt and uncertainty in OCD. Also, relationships between lateral asymmetries of ERP components and cognitive asymmetries for a dichotic syllable task will provide data for evaluating hypotheses of left hemisphere overactivation and dysfunction in OCD. The proposed project will also investigate: a) the diagnostic specificity of ERP findings for OCD by using a social phobic control group; b) relationships between ERP abnormalities and symptom type and severity in OCD; and c) whether key ERP abnormalities in OCD represent stable (trait) characteristics or change following successful treatment with an antiobsessional medication. Specifically, 40 OCD patients, 20 social phobic controls and 20 normal controls will be tested on four ERP tasks; a Passive Attention Task, an Active Attention Task, a Directed Attention Task and a Choice Reaction Time CNV Task, as well as on a dichotic consonant-vowel discrimination task. OCD patients and social phobics are tested after a minimum drug- free period of 14 days, and OCD patients are retested following 12 weeks of treatment with an antiobsessional mediation, fluoxetine in most cases. Normal controls will be retested at the same test-retest intervals as OCD patients.