Sustainability and Supply Chain Benefits of Antibiotic Replacement Technology for Canadian and UK Livestock Sectors

饲料使用量约占家禽养殖场温室气体排放的78%。为了应对英国、加拿大(以及全球)日益增长的提高家禽生产可持续性的需求，该联盟(英国雅顿生物技术和TrustBIX CA)希望通过利用噬菌体技术来解决家禽中经济上虚弱和饲料利用率低的疾病-坏死性肠炎(NE)和亚临床坏死性肠炎(SNE)。预防性抗生素生长促进剂(AGPs)目前被用于控制坏死性肠炎(NE)，一种由病原体_产气荚膜梭菌(CP)引起的肠道疾病。NE对肠道健康有重大影响，特别是在肉鸡行业，每年在全球造成约60亿美元的损失。预防性使用AGPs可能会对有益的肠道细菌产生负面影响，由于消费者的压力和对抗菌素耐药性的担忧，许多国家正在禁止或停止使用AGPs。然而，在CP缺乏有效控制的情况下，这将增加FCR并威胁家禽生产的可持续性，导致需要更多的饲料，并使禽类达到最佳体重的生长期更长。英国雅顿生物技术公司开发了一种新型噬菌体鸡尾酒，一种天然饲料补充剂，以对抗CP，增强肠道健康，降低NE和SNE的风险。通过这项为期24个月的合作工业研究项目，雅顿公司正寻求与加拿大TrustBIX公司合作，将这项技术的开发扩展到加拿大家禽和其他畜牧业。随着该行业远离AGP，家禽生产性能下降，治疗性抗生素的使用增加。一种维持肠道健康的天然产品将通过减少FCR、土地利用变化、粪便中挥发性固体的排泄和农场能源使用，显著减少温室气体排放，从而在没有AGP的情况下改善家禽部门的可持续性。该项目将确认和预测这些可持续性声明，制定适当的衡量标准，并开发一个平台，通过供应链跟踪使用雅顿的Sustavia技术生产的食品，将可持续性属性货币化。该项目将通过使用专门用于对抗CP的噬菌体为NE提供控制，为加拿大和英国的家禽行业增加价值。它将进一步增强全国领先的可持续牲畜可追溯平台，使其适用于家禽部门，并通过引入新的AI/ML能力来增强其分析能力，以支持提高数据质量和分析。

Feed usage accounts for ~78% of poultry farming greenhouse-gas-emissions. In response to a growing demand to enhance sustainability in poultry production in the UK, Canada (and worldwide), the consortium (Arden Biotechnology, UK & TrustBIX CA) wishes to address the financially debilitating and poor feed utilising disease in poultry, necrotic enteritis (NE) and subclinical necrotic enteritis (SNE), by utilising bacteriophage technology.Prophylactic antibiotic growth promoters (AGPs) are currently used to control necrotic enteritis (NE), an enteric gut disease caused by the pathogen _Clostridium perfringens_ (CP). NE has a major impact on gut health, particularly in the broiler industry, costing it ~US$6billions per year globally. The prophylactic use of AGPs can negatively impact beneficial gut bacteria and is being banned or withdrawn in many countries due to consumer pressure and concerns on antimicrobial resistance. This will however increase FCR and threaten the sustainability of poultry production in the absence of an effective control for CP, causing more feed to be required and a longer growing period for birds to reach optimum weight.Arden Biotechnology, UK (Arden) have developed a novel bacteriophage cocktail, a natural feed supplement (NFS) to combat CP, enhance gut health and reduce the risk of NE and SNE. Through this collaborative 24 months industrial research project, Arden are seeking to extend the development of this technology to apply to the Canadian poultry and other livestock sectors in partnership with TrustBIX Inc. Canada.As the industry moves away from AGPs, poultry performance decreases and therapeutic antibiotic use increases. A natural product that maintains gut health will improve sustainability of the poultry sector in the absence of AGPs by effecting a significant reduction in greenhouse gas emissions by reducing FCR, land use change, excretion of volatile solids in manure and on farm energy use. This project is to confirm and predict these sustainability claims, develop appropriate metrics, and develop a platform to track food produced using Arden's Sustavian technology through the supply chain, to monetise the sustainability attributes.This project will add value to the Canadian and UK poultry sectors by delivering a control for NE using bacteriophage specifically to combat CP. It will further enable the enhancements to a nationally leading sustainable livestock traceability platform, adapting it for use in the poultry sector and enhancing its analytical capacity with the introduction of new AI/ML capabilities to support the enhancements of data quality and analysis.