BEHAVIORAL AND METABOLIC PRECURSORS OF OBESITY

描述（改编自申请人的摘要）： 本届临床医生科学家发展奖将获得全面的 对假定风险的理解和研究技能 在婴儿和儿童肥胖的发展因素。 的 候选人将接受广泛的，但深入的遗传审查， 与发展有关的心理、营养和代谢问题 肥胖症。 一个重点将是在该地区的化学感觉刺激， 摄食行为、饥饿感和饱腹感。 能源消耗领域 将被充分探讨，因为它与肥胖的发展有关， 摄食行为 候选人将发展研究方法的技能 在这些领域，使用拟议的婴儿生长研究作为实践 这是对这些问题的科学探索。 候选人将参加一项前瞻性研究，评估，单独和 交互式地，所提出的五种肥胖症的预测值 因素：1）母亲肥胖，2）婴儿吸吮方式，3）食物摄入，4） 总能量消耗; 5）静息能量消耗。 婴儿 生长研究是对高危婴儿（出生于 肥胖母亲）用于肥胖和低风险婴儿（瘦母亲所生）。 在以前的研究中，一个充满活力的婴儿吸吮方式与高压， 吸吮，增加热量消耗的第一年的生活，和低 能量消耗水平预示着一年后的过度肥胖。 在 婴儿生长研究，所有因素将在 同一项研究，候选人将参加评估的所有阶段。 婴儿吸吮行为、食物摄入、能量的多项测量 支出和身体组成将允许测试的相互作用， 变量 通过4年的生活肥胖评估将允许 对这些变量的预测性进行更长时间的分析。

DESCRIPTION (Adapted from the Applicant's Abstract): The candidate for this Scientist Development Award for Clinicians will obtain a comprehensive understanding about and research skills related to the putative risk factors in the development of obesity in infants and children. The candidate will receive a broad, but in depth review of the genetic, psychological, nutritional and metabolic issues related to the development of obesity. A focus will be in the area of chemosensory stimulation of ingestive behavior, hunger, and satiety. The area of energy expenditure will be fully explored as it relates to the development of obesity and ingestive behavior. The candidate will develop skills in research methods in these areas, using the proposed Infant Growth Study as a practice exercise and as a scientific exploration of these issues. The candidate will participate in a prospective study assessing, singly and interactively, the predictive value for adiposity of the proposed five factors: 1) maternal obesity, 2) infant sucking style, 3) food intake, 4) total energy expenditure, and 5) resting energy expenditure. The Infant Growth Study is a prospective examination of infants at high risk (born of obese mothers) for obesity and infants at low risk (born of lean mothers). In previous studies, a vigorous infant sucking style with high pressure sucking, increased caloric consumption for the first year of life, and low energy expenditure levels predicted excess adiposity at one year. In the Infant Growth Study, all factors will be evaluated prospectively in the same study and the candidate will participate in all phases of assessment. Multiple measures of infant sucking behavior, food intake, energy expenditure and body composition will allow for tests of interactions of the variables. Adiposity assessments through 4 years of life will allow for longer analysis of the predictiveness of these variables.