Bioenergetics in Health and Diseases

摘要 请求为题为《健康和疾病中的生物能量学》的Keystone研讨会提供支助， 由Shingo Kajimura博士、Anna Krook博士和Jared Rutter博士组织。会议将在Keystone举行， 科罗拉多州，2023年1月15日至19日。 生物能量缺陷是代谢性疾病、年龄相关疾病和癌症的核心；然而， 启动者对这些过程的了解仍然不够。在过去的几年里，这个领域一直在 因为几次突破而转型，并继续扩大。例如，新的机制 发现了徒劳的骑车行为。线粒体代谢的新调节剂及其在代谢中的作用 已有疾病和癌症的报道。代谢组学、脂类组学和 蛋白质组学技术正在迅速增长。因此，有动力组织一次会议， 专注于代谢性疾病、运动和癌症背景下这一令人兴奋的新兴话题。这个 该计划包括一个多学科演讲者阵容，将涵盖线粒体生物能量学、 癌症代谢、运动生理学和代谢性疾病。此外，本次会议还将举行 与Keystone研讨会会议联合举办的“脂肪组织：让好脂肪充满活力”。这对情侣将 特色三个共享会议：健康和疾病中的代谢流，生物能量学和能量稳态， 脂肪组织和新陈代谢疾病。预计这些主题将创造无数新的 协作和跨学科互动。总而言之，这次会议的目的是讨论 在代谢疾病的背景下生物能量学领域出现的新问题 生物体水平，除了促进现有的和新的研究人员在该领域的协同作用之外 能量代谢。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Bioenergetics in Health and Diseases, organized by Drs. Shingo Kajimura, Anna Krook and Jared Rutter. The conference will be held in Keystone, Colorado from January 15-19, 2023. Bioenergetic defects lie at the heart of metabolic disease, age-related disease, and cancer; however, what initiates the processes remain insufficiently understood. Over the last several years, the field has been transformed because of several breakthroughs and continues to expand. For instance, new mechanisms of futile cycling were identified. Novel regulators of mitochondrial metabolism and their roles in metabolic diseases and cancer have been reported. The sensitivity and resolution of metabolomics, lipidomics, and proteomics technologies are rapidly increasing. Thus, there is momentum to organize a conference that focuses on this exciting and emerging topic in the context of metabolic diseases, exercise, and cancer. The program includes a multi-disciplinary speaker lineup that will cover topics such as mitochondrial bioenergetics, cancer metabolism, exercise physiology, and metabolic diseases. Moreover, this conference will be held jointly with the Keystone Symposia conference, “Adipose Tissue: Energizing Good Fat.” This pairing will feature three shared sessions: Metabolic Flux in Health and Disease, Bioenergetics and Energy Homeostasis, and Adipose Tissue and Metabolic Diseases. It is anticipated that these topics will create numerous new collaborations and cross-disciplinary interactions. All in all, this conference was designed to discuss the emerging questions in the field of bioenergetics in the context of metabolic diseases at molecular and organismal levels, in addition to facilitating synergy between established and new investigators in the field of energy metabolism.