Bioenergetics in Health and Diseases

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ABSTRACT Support is requested for a Keystone Symposia conference entitled Bioenergetics in Health and Diseases, organized by Drs. Shingo Kajimura, Anna Krook and Jared Rutter. The conference will be held in Keystone, Colorado from January 15-19, 2023. Bioenergetic defects lie at the heart of metabolic disease, age-related disease, and cancer; however, what initiates the processes remain insufficiently understood. Over the last several years, the field has been transformed because of several breakthroughs and continues to expand. For instance, new mechanisms of futile cycling were identified. Novel regulators of mitochondrial metabolism and their roles in metabolic diseases and cancer have been reported. The sensitivity and resolution of metabolomics, lipidomics, and proteomics technologies are rapidly increasing. Thus, there is momentum to organize a conference that focuses on this exciting and emerging topic in the context of metabolic diseases, exercise, and cancer. The program includes a multi-disciplinary speaker lineup that will cover topics such as mitochondrial bioenergetics, cancer metabolism, exercise physiology, and metabolic diseases. Moreover, this conference will be held jointly with the Keystone Symposia conference, “Adipose Tissue: Energizing Good Fat.” This pairing will feature three shared sessions: Metabolic Flux in Health and Disease, Bioenergetics and Energy Homeostasis, and Adipose Tissue and Metabolic Diseases. It is anticipated that these topics will create numerous new collaborations and cross-disciplinary interactions. All in all, this conference was designed to discuss the emerging questions in the field of bioenergetics in the context of metabolic diseases at molecular and organismal levels, in addition to facilitating synergy between established and new investigators in the field of energy metabolism.