GENETICALLY DETERMINED IMMUNODEFICIENCIES--ANALYSES OF DEFECTS AND THERAPIES

遗传决定的免疫缺陷——缺陷分析和治疗

• 批准号: 3738838
• 负责人: REBECCA H. BUCKLEY
• 金额: --
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3738838
• 关键词: cellular pathology; human subject; immunogenetics; inborn immunodeficiency; molecular pathology; myeloid stem cell; thymus; tissue mosaicism

The purpose of this study is to define the cellular and molecular bases of the different human primary immunodeficiency disorders so that permanent and/or more effective therapy can be developed. The creation of bone marrow stem cell chimeras has also allowed us a unique opportunity to examine the cellular and molecular bases of human thymic education.

这项研究的目的是定义细胞和分子碱基 在不同的人类原发性免疫缺陷障碍中 可以开发永久和/或更有效的疗法。 创造 骨髓干细胞嵌合体也使我们成为独特的 检查人胸腺的细胞和分子碱基的机会 教育。