ADRENERGIC RECEPTOR MUTATIONS AND SALT SENSITIVE HYPERTENSION

肾上腺素受体突变和盐敏感性高血压

• 批准号: 3738858
• 负责人: LAURA P. SVETKEY
• 金额: --
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3738858
• 关键词: African American; adrenergic receptor; dietary sodium; essential hypertension; family genetics; female; gene mutation; genetic polymorphism; human subject; male; nutrition related tag; phenotype

The purpose of this study is to investigate the genetic basis of essential hypertension in African American men and women. We hypothesize that genetic variability in the adrenergic receptors leads to salt sensitivity, and thus to the pathogenesis of hypertension in Blacks. We are testing this hypothesis using robust sib-pair analysis, with the adrenergic receptors as candidate genes for the phenotype salt sensitivity.

本研究的目的是探讨遗传基础， 非裔美国男性和女性的原发性高血压。 我们假设 肾上腺素能受体的遗传变异导致了盐的产生 敏感性，从而对黑人高血压的发病机制。 我们 正在使用强大的同胞对分析来测试这一假设， 肾上腺素能受体作为表型盐的候选基因 灵敏度