CHILDHOOD MALNUTRITION EFFECTS ON STRESS RESPONSE

儿童营养不良对应激反应的影响

• 批准号: 2033202
• 负责人: LIA C. H. FERNALD
• 金额: $ 1.19万
• 依托单位: UNIVERSITY OF LONDON INST OF CHILD HLTH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-13 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2033202
• 关键词: CHILDHOOD; MALNUTRITION; EFFECTS; STRESS; RESPONSE

Childhood malnutrition is a public health problem of global proportions. Stunted children have numerous developmental difficulties, including deficits in cognitive functioning and poor school performance. Research with animals has demonstrated a link between early malnutrition and heightened emotional reactivity, leading to the hypothesis that stress could interfere with cognitive functioning. However, there has been almost no research with humans exploring this possibility. In my proposed doctoral research, I will investigate the role of impaired stress response as a potential mediating variable contributing to negative developmental outcomes in malnourished children. I will test the hypothesis that children who have suffered a history of malnutrition are less able to adapt to novel environments, and become frustrated and anxious more easily than adequately nourished children. To address this important question, stunted and non-stunted Jamaican children will be presented with psychological stressors (e.g. interview, mental arithmetic, frustrating tasks) and physical stressors (e.g. isometric handgrip). The stress response of the malnourished and adequately nourished children will be compared using behavioral measures in combination with physiological measures of the cardiovascular, adrenocortical, and autonomic nervous systems. The findings of this research will increase our understanding of how heightened susceptibility to stress may contribute to the poor cognitive and social development of malnourished children.

儿童营养不良是全球公共卫生问题 比例。发育不良的孩子有许多发育 困难，包括认知功能的缺陷和不良 学校表演。用动物的研究证明了一个链接 在早期营养不良和情绪增强之间， 导致压力可能干扰认知的假设 功能。但是，几乎没有与人类的研究 探索这种可能性。在我提出的博士研究中，我将 研究压力反应受损作为潜力的作用 中介变量导致负面发展结果 营养不良的孩子。我将检验以下假设 遭受营养不良史的适应性较低 新颖的环境比 充分滋养的孩子。为了解决这个重要问题， 牙买加儿童发育不良和不受欢迎的儿童 心理压力源（例如访谈，精神算术， 令人沮丧的任务）和身体压力源（例如等距手夹）。 营养不良和充分滋养的压力反应 将使用联合行为措施比较儿童 通过心血管，肾上腺皮质和 自主神经系统。这项研究的发现将增加 我们对压力敏感性的增强的理解可能 有助于不良的认知和社会发展 营养不良的孩子。