Evolutionary history and impact of adeno-associated viruses in Australia

澳大利亚腺相关病毒的进化历史和影响

• 批准号: DP150101253
• 负责人: Prof Ian Alexander
• 金额: $ 32.39万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-02-27 至 2018-02-26
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150101253
• 关键词: Evolutionary; history; impact; adeno; associated

Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the potential impact that these viral invasions had on the evolutionary development of their ancestral hosts will be investigated. This could facilitate previously unattainable insights into both AAV and marsupial evolution, with broader implications relevant to the advancement of the fields of virology and mammalian evolution.

最近积累的证据表明，澳大利亚是一个理想的封闭模型系统，在这个系统中可以阐明一组被称为腺相关病毒(AAVs)的非致病病毒的进化历史。该项目旨在通过古代病毒入侵澳大利亚有袋类动物基因组留下的分子化石印记，追溯AAVs数千万年的进化史。同时，这些病毒入侵对其祖先宿主进化发展的潜在影响将被调查。这可以促进对AAV和有袋类进化的以前无法获得的深入了解，对病毒学和哺乳动物进化领域的进步具有更广泛的影响。