Evolutionary history and impact of adeno-associated viruses in Australia

最近积累的证据表明，澳大利亚是一个理想的封闭模型系统，用于阐明一组称为腺相关病毒（aav）的非致病性病毒的进化史。该项目旨在通过澳大利亚有袋动物基因组中古代病毒入侵留下的分子化石印记，追溯数千万年的aav进化史。同时，这些病毒入侵对其祖先宿主进化发展的潜在影响将被研究。这可以促进对AAV和有袋动物进化的以前无法实现的见解，对病毒学和哺乳动物进化领域的进步具有更广泛的影响。

Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the potential impact that these viral invasions had on the evolutionary development of their ancestral hosts will be investigated. This could facilitate previously unattainable insights into both AAV and marsupial evolution, with broader implications relevant to the advancement of the fields of virology and mammalian evolution.