LEARNING AND MEMORY IN PET CBF STUDIES OF SCHIZOPHRENIA

拟议的研究将检查脑部局部功能障碍。 测定精神分裂症患者的局部脑血流量(CBF) 在言语和面部记忆任务执行过程中的正常对照。这个 对学习和记忆的关注是由这些功能的证据促使的 在精神分裂症中受损程度不成比例。建议进行的研究 这只RO1将使用“神经行为探测器”的方法来帮助识别 记忆任务执行过程中的异常激活区。CBF 将用15氧标记的水(“慢进丸”)进行PET测量 方法)。受试者为精神分裂症患者和正常对照组。 (社会人口学平衡)，他们都将在休息时进行研究 基线和3种激活条件。 要考察的实验维度是学习(习得)与 回忆和言语对面部的刺激。每个细胞将有60名受试者， 30名男性，30名女性，15名精神分裂症患者和15名正常对照 性别。根据这些实验的结果和神经心理学 在MHCRC中进行的研究，其他维度显示差异 精神分裂症的损害可以进行检查。这些可能是列表与 配对-联想学习，情绪化与非情绪化，或“程序化”VS “陈述性”记忆。 正常对照组的假设是，实验条件 会不同地激活大脑中参与学习的区域 检索过程。关于初选的证据有一些趋同 在记忆中的作用海马体和相关皮质，颞叶和 背外侧额叶皮质区域。在正常情况下，我们可以测试 假设收购的活跃度将比 回忆，词语的侧向效应(L；R)对面孔(R&>T；L)。在早些时候 对大脑皮质脑血流的研究发现，激活的特异性是 与更好的性能相关联，这可以在 目前对皮质下区域进行了调查。我们将研究哪一个 精神分裂症患者这一系统的某些方面受到损害，并测试 激活异常与症状相关的假说 严重程度和神经心理缺陷。

The proposed studies will examine regional brain dysfunction in schizophrenia by measuring local cerebral blood flow (CBF) in patients and normal controls during performance of verbal and facial memory tasks. The focus on learning and memory is prompted by evidence that these functions are disproportionately impaired in schizophrenia. The studies proposed in this RO1 will use the "Neurobehavioral Probe" method to help identify regions of abnormal activation during performance of memory tasks. CBF will be measured with PET using 15-Oxygen labelled water (the "slow bolus" method). Subjects will be patients with schizophrenia and normal controls (balanced socio-demographically), and they will each be studied at resting baseline and 3 activation conditions. The experimental dimensions to be examined are learning (acquisition) vs recall and verbal vs facial stimuli. There will be 60 subjects per cell, 30 men 30 women, 15 patients with schizophrenia and 15 normal controls per gender. Based on results of these experiments and neuropsychological studies performed in the MHCRC, other dimensions which show differential impairment in schizophrenia can be examined. These could be list vs paired-associate learning, emotional vs nonemotional, or "procedural" vs "declarative" memory. The hypothesis for normal controls is that the experimental conditions will differentially activate brain regions engaged in learning and retrieval processes. There is some convergence of evidence for the primary role in memory of the hippocampus and associated cortex, temporal and dorsolateral frontal cortical regions. In normals we can test the hypothesis that activation will be greater for acquisition relative to recall, with laterality effects for words (L>R) vs faces (R>L). In earlier studies of cortical CBF we found specificity of activation to be associated with better performance, and this can be extended in the present investigation to subcortical regions. We will examine which aspects of this system are impaired in schizophrenia, and test the hypothesis that abnormalities in activation are related to symptom severity and neuropsychological deficits.