IMAGING THE RESPONDING SI NEURONAL POPULATION

对响应 SI 神经元群进行成像

• 批准号: 2270480
• 负责人: Mark A Tommerdahl
• 金额: $ 12.46万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2270480
• 关键词: NMDA receptors; Saimiri; autoradiography; brain electrical activity; brain imaging /visualization /scanning; brain metabolism; cats; evoked potentials; infrared microscopy; sensory receptors; skin; somesthetic sensory cortex; stimulus /response

The proposed experiments focus on studies of patterns of stimulus evoked activity in somatosensory cortex (SI), and in particular, on the activation patterns evoked by repetitive skin stimulation. In the 01 year, animal experiments using the C14-2DG metabolic mapping method (2DG) and the infrared optical recording method for imaging intrinsic cortical signals (IR imaging) will be performed. The goal is to obtain and compare IR and 2DG images of the cortical response to the same stimulus conditions. In years 02-05, the IR optical recording technique will be employed to characterize the effects on stimulus evoked SI activity patterns of (i) NMDA receptor block, (ii) different frequencies of vibrotactile stimulation, and (iii) differing spatiotemporal patterns of skin stimulation. It is anticipated that the proposed studies will provide novel and useful information about the consequences of stimulus- evoked interactions among the multiple and spatially distributed neuronal populations activated by cutaneous stimuli. The information to be obtained should fill major gaps in what is currently known about the somatosensory cortical response to skin stimulation-gaps attributable principally to inadequacies of the methodologies which, at least to date, have been emphasized by experiments. In addition, the findings should provide direction to ongoing modeling and simulation studies of stimulus- directed somatosensory cortical network dynamics and the underlying neural mechanisms.

拟议的实验侧重于诱发刺激模式的研究 体感皮层 (SI) 的活动，特别是 由重复的皮肤刺激引起的激活模式。 在01 年，动物实验采用C14-2DG代谢作图方法（2DG） 以及用于对内在皮质进行成像的红外光学记录方法 将执行信号（红外成像）。 目标是获得和 比较皮质对相同刺激的反应的 IR 和 2DG 图像 状况。 02-05年，IR光学记录技术将 用于表征刺激诱发 SI 活动的影响 (i) NMDA 受体阻断的模式，(ii) 不同频率 振动触觉刺激，以及（iii）不同的时空模式 皮肤刺激。 预计拟议的研究将 提供有关刺激后果的新颖且有用的信息 引起多个和空间分布的神经元之间的相互作用 受到皮肤刺激而激活的人群。 需提供的信息 所获得的成果应该填补目前已知的主要空白 体感皮质对皮肤刺激的反应-间隙归因 主要是由于方法的不足，至少到目前为止， 已经通过实验强调了。 此外，研究结果应 为正在进行的刺激建模和模拟研究提供方向 定向体感皮质网络动力学及其底层 神经机制。