OMEGA-3 FATTY ACIDS AND CARDIOVASCULAR RISK FACTORS

心血管疾病仍然是美国的头号死因。 最近的临床和实验室研究表明， 心血管疾病中的omega-3多不饱和脂肪酸(鱼油)。 许多鱼油研究表明，鱼油可以降低血压， 血脂、血小板计数、血小板聚集率。海洋石油或 欧米茄-3脂肪酸、二十碳五烯酸(EPA)和二十二碳六烯酸 (DHA)似乎是可以有利地改变这些的主要成分 可能与心血管疾病相关的因素。 初步研究表明，omega- 3大鼠离体主动脉中的脂肪酸、DHA和EPA。有非常多的 从文献中可获得的关于血管的直接影响的数据很少 Omega-3脂肪酸和没有确定直接血管作用的报道 在存在心血管危险因素的情况下，omega-3脂肪酸的含量。 这些危险因素包括高血压、年龄、吸烟和 血液中胆固醇水平升高。因此，它的具体目标是 将检验DHA和EPA诱导的血管松弛的假设 部分地解释了omega-3的保护和/或预防作用 心血管疾病中的脂肪酸是：定义和比较 DHA和EPA对增龄大鼠血管组织的血管作用 测定omega-3脂肪酸诱导的大鼠血管反应 高脂血症饮食，检测钙介导的血管效应 DHA和EPA在正常血压大鼠体内的表达，并比较钙离子介导的 欧米茄-3脂肪酸对高血压大鼠的血管反应。 在体外，胸主动脉的隔离浴液灌流将用于 评估血管张力的变化。血管将会被平衡到 在最佳的Krebs-Ringer重碳酸盐缓冲溶液中放置60-90分钟 紧张。将测量等长力和累积浓度- 将生成对omega-3脂肪酸的响应曲线。通过 确定omega-3脂肪酸对血管的影响是一个有效的基础 对于疾病治疗，即可以开发饮食修改。这个 拟议的研究将通过以下方式支持和改进当前的护理实践 在#年可能启动二级和三级预防战略 心血管疾病。

Cardiovascular disease remains the number one cause of death in America. Recent clinical and laboratory investigations suggest a protective role for omega-3 polyunsaturated fatty acids (fish oils) in cardiovascular disease. Numerous fish oil studies have demonstrated a reduction in blood pressure, serum lipids, platelet count and platelet aggregation. The marine oils or omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) appear to be the main components which can favorably alter these factors that may be associated with cardiovascular disease. Preliminary investigations have demonstrated relaxation responses to omega- 3 fatty acids, DHA and EPA in the isolated rat aorta. There are very little data available from the literature on the direct vascular effects of omega-3 fatty acids and no reports establishing the direct vascular effects of omega-3 fatty acids in the presence of cardiovascular risk factors. These risk factors include hypertension, age, cigarette smoking, and elevated levels of blood cholesterol. Therefore, the specific aims that will test the hypothesis that vascular relaxation induced by DHA and EPA way, in part, explain the protective and/or preventive role of omega-3 fatty acids in cardiovascular disease are to: define and compare the vascular effects of DHA and EPA on rat vascular tissue with increased age, determine the omega-3 fatty acids-induced vascular responses in rats fed a hyperlipidemia-inducing diet, examine the calcium-mediated vascular effects of DHA and EPA in normotensive rats, and compare the calcium-mediated vascular responses of omega-3 fatty acids in hypertensive rats. In vitro isolated bath perfusion of the thoracic aorta will be employed to assess changes in vascular tension. The vessels will be equilibrated for 60-90 minutes in Krebs-Ringer bicarbonate buffer solution under optimal tension. Isometric force will be measured and cumulative concentration- response curves to the omega-3 fatty acids will be generated. By determining the vascular effects of omega-3 fatty acids, a valid foundation for disease treatment, i.e. dietary modification can be developed. The proposed research will support and improve current nursing practice through the possible initiation of secondary and tertiary prevention strategies in cardiovascular disease.