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Diet, Endothelial Function and Pediatric Hyperlipidemia

饮食、内皮功能和小儿高脂血症

基本信息

批准号：
7632787
负责人：
MARY B ENGLER
金额：
$ 49.82万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-04-01 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7632787
关键词：
9 year old Adherence Adolescence Adolescent Adult Affect Age Age-Years American Heart Association Antiatherogenic Apolipoprotein E Apolipoproteins B Arteries Atherosclerosis Behavior Behavior Therapy Biological Markers Blood Blood Vessels Cardiovascular system Cause of Death Cell Adhesion Molecules Child Childhood Cholesterol Class Clinical Clinical Research Clinical Trials Consumption Controlled Clinical Trials Coronary Arteriosclerosis Coronary heart disease Country Coupled Crossover Design Daily Development Diet Dietary Cholesterol Dietary Component Dietary Fiber Dietary Intervention Dietary Supplementation Disease Disease Management Docosahexaenoic Acids Dose Double-Blind Method E-Selectin Early Diagnosis Effectiveness Eicosapentaenoic Acid Endothelial Cells Endothelium Experimental Models F2-Isoprostanes Familial Combined Hyperlipidemia Familial Hypercholesterolemia Family history of Fatty Acids Fatty acid glycerol esters Fishes Food Functional disorder Future Gene Mutation General Population Genotype Grant Health Health Care Costs Heart High Density Lipoprotein Cholesterol High Density Lipoproteins Hyperlipidemia Hypertension Incidence Individual Inflammation Inflammatory Inflammatory Response Inherited Injury Intercellular adhesion molecule 1 Interleukin-1 Intervention Intervention Studies LDL Cholesterol Lipoproteins Leukocytes Lipids Lipoprotein (a)Lipoprotein (a-)Lipoproteins Low-Density Lipoproteins Measurement Measures Mediating Mediterranean Diet Monitor Monounsaturated Fatty Acids Morbidity - disease rate Nitric Oxide Nuts Oleic Acid Oleic Acids Olive oil preparation Omega-3 Fatty Acids Online Systems Operative Surgical Procedures Outcome Oxidative Stress P-Selectin Pharmacotherapy Phase Placebo Control Plants Plasma Platelet Activation Prevalence Prevention Process Production Property Protocols documentation Quality of life Randomized Recommendation Research Resistance Resolution Risk Role Secondary Prevention Smooth Muscle Myocytes Structure Supplementation Testing Therapeutic Triglycerides Ultrasonography United States Vascular Cell Adhesion Molecule-1 Vasodilation Very low density lipoprotein Week alpha-Linolenic Acid atherogenesis base brachial artery cell motility cost effective cytokine day design early onset fruits and vegetables group counseling hypercholesterolemia improved insight intervention program lipid disorder lipoprotein-associated phospholipase A(2)low density lipoprotein inhibitor monocyte mortality oxidation oxidized low density lipoprotein particle prevent programs therapy design

项目摘要

Coronary heart disease (CHD) continues to be the leading cause of death in the United States. Children with elevated cholesterol levels are especially vulnerable and are at high risk for early onset CHD. Endothelial dysfunction, the earliest phase of coronary atherosclerosis, is present in children with elevated cholesterol levels as early as 8 years of age. The long term objective of this study is to develop dietary interventions for the prevention and treatment of endothelial dysfunction in children with common lipid disorders including familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH). Increasing evidence suggests that the Mediterranean diet and ?-3 fatty acids found in fish have cardioprotective effects. The specific aims of the study are to: determine whether a Mediterranean diet alone or combined with ?-3 fatty acids (eicosapentaenoic acid, docosahexaenoic acid or eicosapentaenoic & docosahexaenoic acids) improve endothelial function; evaluate the effects of the dietary interventions on lipids and lipoprotein subclasses; evaluate the effects of the dietary interventions on biomarkers for oxidative stress and inflammation. This study is a randomized, double-blind, placebo-controlled clinical trial that includes 102 children (ages 8-18) treated with the Mediterranean diet and ?-3 fatty acid supplements. A dietary educational behavioral intervention will be conducted over 6 months with individual counseling, group sessions and an interactive web-based program. Endothelial function will be measured non-invasively by high resolution ultrasound of the brachial artery at baseline, 6, 12, 18 and 24 weeks. This study is unique because it is a new intervention designed for children at high risk for early CHD with a dietary component and supplementation with ?-3 fatty acids. If effective, this intervention would be broadly applicable and lend valuable insight about dietary therapy to prevent the progression of CHD in hyperlipidemic children.

冠心病（CHD）仍然是美国的主要死亡原因。儿童胆固醇水平升高尤其容易受到影响，并且是早发冠心病的高风险。内皮功能障碍是冠状动脉粥样硬化的最早阶段，存在于胆固醇升高的儿童中早在8岁的水平。本研究的长期目标是制定饮食干预措施，预防和治疗常见脂质紊乱儿童的内皮功能障碍，包括家族性高胆固醇血症（FH）和家族性混合型高脂血症（FCH）。越来越多的证据表明地中海饮食和？在鱼类中发现的3种脂肪酸具有心脏保护作用。的具体目标这项研究是：确定地中海饮食是单独还是与？3脂肪酸（二十碳五烯酸、二十二碳六烯酸或二十碳五烯酸和二十二碳六烯酸）改善内皮功能;评价饮食干预对脂质和脂蛋白亚类的影响; 评估饮食干预对氧化应激和炎症生物标志物的影响。这研究是一项随机、双盲、安慰剂对照的临床试验，包括102名儿童（8-18岁）用地中海饮食治疗，3脂肪酸补充剂。饮食教育行为干预将在6个月内进行，包括个人咨询，小组会议和互动基于Web的程序。内皮功能将通过高分辨率超声非侵入性地测量，基线、6、12、18和24周时的肱动脉。这项研究是独一无二的，因为它是一种新的干预措施专为儿童在高风险的早期冠心病与饮食组成部分和补充？- 3脂肪 acids.如果有效，这种干预将广泛适用，并提供有关饮食疗法的宝贵见解预防高血脂儿童CHD的进展。